Induction of MASH-like pathogenesis in the Nwd1 −/− mouse liver

Induction of MASH-like pathogenesis in the Nwd1 −/− mouse liver

Abstract Endoplasmic reticulum (ER) stores Ca2+ and plays crucial roles in protein folding, lipid transfer, and it’s perturbations trigger an ER stress. In the liver, chronic ER stress is involved in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic d...

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Main Authors: Seiya Yamada, Hayato Ogawa, Miona Funato, Misaki Kato, Kazuhiko Nakadate, Tomoya Mizukoshi, Kiyoharu Kawakami, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Shin-ichi Sakakibara
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07717-5
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