Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia
In this study, aimed to evaluate the sensitivity and specificity of cerebral oximetry and EtCO2 values in non-invasive diagnosis and monitoring of hypercapnia. This study enrolled pediatric patients admitted to and mechanically ventilated at the Pediatric Intensive Care Unit of Gaziantep Univ...
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Hacettepe University Institute of Child Health
2016-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1130 |
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| author | Seher Erdoğan Arzu Oto Mehmet Boşnak |
| author_facet | Seher Erdoğan Arzu Oto Mehmet Boşnak |
| author_sort | Seher Erdoğan |
| collection | DOAJ |
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In this study, aimed to evaluate the sensitivity and specificity of cerebral oximetry and EtCO2 values in non-invasive diagnosis and monitoring of hypercapnia. This study enrolled pediatric patients admitted to and mechanically ventilated at the Pediatric Intensive Care Unit of Gaziantep University Faculty of Medicine Hospital between January 2014 and January 2015. Patients' age, gender, diagnosis, ventilatory parameters, a measured of the mean end-tidal carbon dioxide value stream method, and the simultaneously monitored arterial blood gas PaCO 2 level and near infrared spectroscopy device (NIRS) measurements were recorded. The mean age of patients was 61 months (min 4-max 193), and there were 8 (53.4%) female and 7 (46.6%) male subjects. A significant correlation was found between PCO2 and NIRS, PCO 2 and EtCO 2 (r = 0.571, p < 0.001). There was a significant positive correlation between EtCO2 and NIRS (r = 0.479, p < 0.001). NIRS levels were significantly higher (p < 0.001) in the group with pCO 2 > 45; EtCO 2 > 40 and pH < 7.35, compared to the group with PCO 2 < 45 EtCO 2 < 40 and ph≥7.35 . The best cut-off point for NIRS to distinguish the groups with PCO 2 > 45 with PCO 2 < 45 was 80.5, with a sensitivity of 65.3%, specificity of 84.3%, and positive and negative predictive values of 81.9% and 69.1%, respectively. The best cut-off point for NIRS to distinguish the groups with EtCO 2 > 40 and EtCO 2 < 40 was 81, with a sensitivity of 62.2%, specificity 77.9%, and positive and negative predictive values of 61.2% and 72.3%, respectively. As for pH < 7.35 and PaCO 2 > 45, while sensitivity of EtCO 2 (at a cut-off point of 40) was 64.9%; the sensitivity of NIRS (at a cut-off point of 80.5) was 28.1%, with EtCO 2 being significantly more sensitive than NIRS (p < 0.001). The results of the present study suggest that NIRS values of above 80 should alert clinicians for hypercapnia associated with increased cerebral blood flow.
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| format | Article |
| id | doaj-art-b23edb4b8d4240e2b0e01ae17bc05cfc |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-b23edb4b8d4240e2b0e01ae17bc05cfc2025-08-20T02:55:21ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-08-0158410.24953/turkjped.2016.04.007Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapniaSeher Erdoğan0Arzu Oto1Mehmet Boşnak2Division of Pediatric Critical Care, Department of Pediatrics, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.Division of Pediatric Critical Care, Department of Pediatrics, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.Division of Pediatric Critical Care, Department of Pediatrics, Gaziantep University Faculty of Medicine, Gaziantep, Turkey. In this study, aimed to evaluate the sensitivity and specificity of cerebral oximetry and EtCO2 values in non-invasive diagnosis and monitoring of hypercapnia. This study enrolled pediatric patients admitted to and mechanically ventilated at the Pediatric Intensive Care Unit of Gaziantep University Faculty of Medicine Hospital between January 2014 and January 2015. Patients' age, gender, diagnosis, ventilatory parameters, a measured of the mean end-tidal carbon dioxide value stream method, and the simultaneously monitored arterial blood gas PaCO 2 level and near infrared spectroscopy device (NIRS) measurements were recorded. The mean age of patients was 61 months (min 4-max 193), and there were 8 (53.4%) female and 7 (46.6%) male subjects. A significant correlation was found between PCO2 and NIRS, PCO 2 and EtCO 2 (r = 0.571, p < 0.001). There was a significant positive correlation between EtCO2 and NIRS (r = 0.479, p < 0.001). NIRS levels were significantly higher (p < 0.001) in the group with pCO 2 > 45; EtCO 2 > 40 and pH < 7.35, compared to the group with PCO 2 < 45 EtCO 2 < 40 and ph≥7.35 . The best cut-off point for NIRS to distinguish the groups with PCO 2 > 45 with PCO 2 < 45 was 80.5, with a sensitivity of 65.3%, specificity of 84.3%, and positive and negative predictive values of 81.9% and 69.1%, respectively. The best cut-off point for NIRS to distinguish the groups with EtCO 2 > 40 and EtCO 2 < 40 was 81, with a sensitivity of 62.2%, specificity 77.9%, and positive and negative predictive values of 61.2% and 72.3%, respectively. As for pH < 7.35 and PaCO 2 > 45, while sensitivity of EtCO 2 (at a cut-off point of 40) was 64.9%; the sensitivity of NIRS (at a cut-off point of 80.5) was 28.1%, with EtCO 2 being significantly more sensitive than NIRS (p < 0.001). The results of the present study suggest that NIRS values of above 80 should alert clinicians for hypercapnia associated with increased cerebral blood flow. https://turkjpediatr.org/article/view/1130end-tidal carbon dioxidehypercapnianear infrared spectroscope |
| spellingShingle | Seher Erdoğan Arzu Oto Mehmet Boşnak Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia The Turkish Journal of Pediatrics end-tidal carbon dioxide hypercapnia near infrared spectroscope |
| title | Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia |
| title_full | Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia |
| title_fullStr | Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia |
| title_full_unstemmed | Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia |
| title_short | Reliability of cerebral oximeter in non-invasive diagnosis and follow-up of hypercapnia |
| title_sort | reliability of cerebral oximeter in non invasive diagnosis and follow up of hypercapnia |
| topic | end-tidal carbon dioxide hypercapnia near infrared spectroscope |
| url | https://turkjpediatr.org/article/view/1130 |
| work_keys_str_mv | AT sehererdogan reliabilityofcerebraloximeterinnoninvasivediagnosisandfollowupofhypercapnia AT arzuoto reliabilityofcerebraloximeterinnoninvasivediagnosisandfollowupofhypercapnia AT mehmetbosnak reliabilityofcerebraloximeterinnoninvasivediagnosisandfollowupofhypercapnia |