Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet
We investigated the preventive effect of lycopene on nonalcoholic steatohepatitis-induced by high-fat diet in rats. Forty male Sprague-Dawley rats were divided into 4 groups. They were fed standard diet, high-fat diet (HFD), high-fat diet plus lycopene at a dose of 2 mg/kg body weight and the high-f...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2010/262179 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159979876581376 |
|---|---|
| author | Ibrahim Halil Bahcecioglu Nalan Kuzu Kerem Metin Ibrahim Hanifi Ozercan Bilal Ustündag Kazim Sahin Omer Kucuk |
| author_facet | Ibrahim Halil Bahcecioglu Nalan Kuzu Kerem Metin Ibrahim Hanifi Ozercan Bilal Ustündag Kazim Sahin Omer Kucuk |
| author_sort | Ibrahim Halil Bahcecioglu |
| collection | DOAJ |
| description | We investigated the preventive effect of lycopene on nonalcoholic steatohepatitis-induced by high-fat diet in rats. Forty male Sprague-Dawley rats were divided into 4 groups. They were fed standard diet, high-fat diet (HFD), high-fat diet plus lycopene at a dose of 2 mg/kg body weight and the high-fat diet lycopene at a dose of 4 mg/kg BW for a period of 6 weeks. Inflammation, steatosis, 𝛼-smooth muscle actin (𝛼-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene. Significantly elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF 𝛼), and serum and liver malondialdehyde (MDA) were observed in rats fed the high-fat diet as compared to the control rats (𝑃<.01). Supplementation with lycopene lowered serum MDA and tumor necrosis factor (TNF-𝛼) levels and elevated liver GSH level (𝑃<.001). Insulin resistance was higher in the rats fed HFD than in rats supplemented with lycopene. The data indicate that supplementation with lycopene can reduce high-fat diet-induced oxidative stress to the cells. |
| format | Article |
| id | doaj-art-b23a7054a88e48cd97fd4be18220ac86 |
| institution | OA Journals |
| issn | 2042-0048 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-b23a7054a88e48cd97fd4be18220ac862025-08-20T02:23:18ZengWileyVeterinary Medicine International2042-00482010-01-01201010.4061/2010/262179262179Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat DietIbrahim Halil Bahcecioglu0Nalan Kuzu1Kerem Metin2Ibrahim Hanifi Ozercan3Bilal Ustündag4Kazim Sahin5Omer Kucuk6Division of Gastroenterology, School of Medicine, Firat University, 23200 Elazig, TurkeyDivision of Gastroenterology, School of Medicine, Firat University, 23200 Elazig, TurkeyDepartment of Biochemistry, School of Medicine, Firat University, 23200 Elazig, TurkeyDepartment of Pathology, School of Medicine, Firat University, 23200 Elazig, TurkeyDepartment of Biochemistry, School of Medicine, Firat University, 23200 Elazig, TurkeyDepartment of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23200 Elazig, TurkeyWinship Cancer Institute, Emory University, Atlanta, GA 30322, USAWe investigated the preventive effect of lycopene on nonalcoholic steatohepatitis-induced by high-fat diet in rats. Forty male Sprague-Dawley rats were divided into 4 groups. They were fed standard diet, high-fat diet (HFD), high-fat diet plus lycopene at a dose of 2 mg/kg body weight and the high-fat diet lycopene at a dose of 4 mg/kg BW for a period of 6 weeks. Inflammation, steatosis, 𝛼-smooth muscle actin (𝛼-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene. Significantly elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF 𝛼), and serum and liver malondialdehyde (MDA) were observed in rats fed the high-fat diet as compared to the control rats (𝑃<.01). Supplementation with lycopene lowered serum MDA and tumor necrosis factor (TNF-𝛼) levels and elevated liver GSH level (𝑃<.001). Insulin resistance was higher in the rats fed HFD than in rats supplemented with lycopene. The data indicate that supplementation with lycopene can reduce high-fat diet-induced oxidative stress to the cells.http://dx.doi.org/10.4061/2010/262179 |
| spellingShingle | Ibrahim Halil Bahcecioglu Nalan Kuzu Kerem Metin Ibrahim Hanifi Ozercan Bilal Ustündag Kazim Sahin Omer Kucuk Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet Veterinary Medicine International |
| title | Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet |
| title_full | Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet |
| title_fullStr | Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet |
| title_full_unstemmed | Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet |
| title_short | Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet |
| title_sort | lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high fat diet |
| url | http://dx.doi.org/10.4061/2010/262179 |
| work_keys_str_mv | AT ibrahimhalilbahcecioglu lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT nalankuzu lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT keremmetin lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT ibrahimhanifiozercan lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT bilalustundag lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT kazimsahin lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet AT omerkucuk lycopenepreventsdevelopmentofsteatohepatitisinexperimentalnonalcoholicsteatohepatitismodelinducedbyhighfatdiet |