Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling.

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling.

Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of...

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Bibliographic Details
Main Authors: Elizabeth Padilla-Banks, Wendy N Jefferson, Brian N Papas, Alisa A Suen, Xin Xu, Diana V Carreon, Cynthia J Willson, Erin M Quist, Carmen J Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002334&type=printable
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