Pharmacodynamics, pharmacokinetics, interactions with other drugs, toxicity and clinical effectiveness of proton pump inhibitors

Pharmacodynamics, pharmacokinetics, interactions with other drugs, toxicity and clinical effectiveness of proton pump inhibitors

The document comprehensively reviews proton pump inhibitors (PPIs), focusing on their pharmacodynamics, pharmacokinetics, drug interactions, toxicity, and clinical efficacy. PPIs irreversibly inhibit the H+/K+-ATPase enzyme in gastric parietal cells, effectively reducing gastric acid secretion. Thes...

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Main Authors: Łukasz Wołowiec, Joanna Osiak-Gwiazdowska, Albert Jaśniak, Michał Janiak, Lidia Wydeheft, Magdalena Łukasiak, Małgorzata Pellowska, Grzegorz Grześk
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
PPIs
pharmacokinetics
interactions
pharmacology
pharmacodynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1507812/full
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