Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies

Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies

Abstract Many efforts targeting amyloid‐β (Aβ) plaques for the treatment of Alzheimer's Disease thus far have resulted in failures during clinical trials. Regional and temporal heterogeneity of efficacy and dependence on plaque maturity may have contributed to these disappointing outcomes. In t...

Full description

Saved in:
Bibliographic Details
Main Authors: Daniel Kirschenbaum, Ehsan Dadgar‐Kiani, Francesca Catto, Fabian F Voigt, Chiara Trevisan, Oliver Bichsel, Hamid Shirani, K Peter R Nilsson, Karl J Frontzek, Paolo Paganetti, Fritjof Helmchen, Jin Hyung Lee, Adriano Aguzzi
Format: Article
Language:English
Published: Springer Nature 2022-11-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
amyloid‐beta
brain
light‐sheet microscopy
tissue clearing
Online Access:https://doi.org/10.15252/emmm.202216789
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.202216789

Similar Items