p53 in colorectal cancer: from a master player to a privileged therapy target

p53 in colorectal cancer: from a master player to a privileged therapy target

Abstract Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide. The pathogenesis of CRC primarily stems from the gradual accumulation of genetic mutations, which drive oncogene (e.g., KRAS) activation and tumor suppressor ge...

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Bibliographic Details
Main Authors: Sicheng Yan, Fuyuan Zhan, Yuxuan He, Yuehong Zhu, Zhihong Ma
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
TP53
p53
Wild-type p53
Mutant p53
GOF
Online Access:https://doi.org/10.1186/s12967-025-06566-4
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