The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study
Abstract Background Our aim was to compare preoperative and postoperative hematological inflammatory parameters in women with endometriosis. Methods Data were collected from 411 patients who underwent laparoscopy surgery between January 2018 and December 2023. Postoperatively, the pathology reports...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-025-03890-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849401817767608320 |
|---|---|
| author | Onur Yavuz Asli Akdoner Kadir Alper Mankan Ufuk Atlihan Begum Ertan Mehmet Guney |
| author_facet | Onur Yavuz Asli Akdoner Kadir Alper Mankan Ufuk Atlihan Begum Ertan Mehmet Guney |
| author_sort | Onur Yavuz |
| collection | DOAJ |
| description | Abstract Background Our aim was to compare preoperative and postoperative hematological inflammatory parameters in women with endometriosis. Methods Data were collected from 411 patients who underwent laparoscopy surgery between January 2018 and December 2023. Postoperatively, the pathology reports indicated ovarian endometrioma in 201 patients (48.9%) and other benign ovarian cysts in 210 patients (51.1%). Subgroups were categorized as stage 1–2 endometriosis (n = 26, 6.3%), stage 3–4 endometriosis (n = 175, 42.6%) and benign ovarian cysts (n = 210, 51.1%). Hematological inflammatory markers and ultrasound findings were evaluated one week before the operation and six weeks after the operation and compared between groups. Statistical analysis was performed by SPSS version 26.0 Not normally distributed parameters were analyzed with the Kruskal Wallis, post hoc and Mann-Whitney U tests. Wilcoxon signed-rank test was used to determine changes before and after treatment. Chi-square test and Fisher precision test were used in the analysis of categorical data. Receiver operating characteristic analysis was performed to calculate the area under the curve, which indicates the average sensitivity of variables and its 95% confidence interval are reported for each assessed parameter. The appropriate cut-off value indicating the sum of the highest sensitivity and specificity was calculated for the most predictive variable. The p value considered statistically significant was < 0.05. Results When comparing the postoperative and preoperative parameters of the main groups, it was determined that the NLR, MLR, and PLR values of both groups increased in the postoperative period, whereas the CA-125 value decreased. In a similar comparison within the subgroups, it was determined that NLR and PLR increased in all three groups in the postoperative period. MLR was found to increase in the stage 3–4 endometriosis and benign ovarian cyst groups. CA-125 decreased in the stage 3–4 endometriosis and benign ovarian cyst groups. RDW > 13.5, PLR > 123.4 and CA-125 > 35 were determined as the cut-off value to predict endometriosis. Conclusion During the follow-ups, we revealed that CA-125 still maintains its effectiveness. There is a lack of existing literature that directly compares hematological inflammatory parameters before and after treatment for endometriosis. |
| format | Article |
| id | doaj-art-b21ce45fd564458ebc07f09784cb9b06 |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-b21ce45fd564458ebc07f09784cb9b062025-08-20T03:37:41ZengBMCBMC Women's Health1472-68742025-07-0125111110.1186/s12905-025-03890-1The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort studyOnur Yavuz0Asli Akdoner1Kadir Alper Mankan2Ufuk Atlihan3Begum Ertan4Mehmet Guney5Department of Obstetrics and Gynecology, Dokuz Eylul University School of MedicineDepartment of Obstetrics and Gynecology, Dokuz Eylul University School of MedicineDepartment of Obstetrics and Gynecology, Dokuz Eylul University School of MedicinePrivate Karatas Hospital, Department of Obstetrics and GynecologyDepartment of Obstetrics and Gynecology, Sandikli State HospitalDepartment of Obstetrics and Gynecology, Dokuz Eylul University School of MedicineAbstract Background Our aim was to compare preoperative and postoperative hematological inflammatory parameters in women with endometriosis. Methods Data were collected from 411 patients who underwent laparoscopy surgery between January 2018 and December 2023. Postoperatively, the pathology reports indicated ovarian endometrioma in 201 patients (48.9%) and other benign ovarian cysts in 210 patients (51.1%). Subgroups were categorized as stage 1–2 endometriosis (n = 26, 6.3%), stage 3–4 endometriosis (n = 175, 42.6%) and benign ovarian cysts (n = 210, 51.1%). Hematological inflammatory markers and ultrasound findings were evaluated one week before the operation and six weeks after the operation and compared between groups. Statistical analysis was performed by SPSS version 26.0 Not normally distributed parameters were analyzed with the Kruskal Wallis, post hoc and Mann-Whitney U tests. Wilcoxon signed-rank test was used to determine changes before and after treatment. Chi-square test and Fisher precision test were used in the analysis of categorical data. Receiver operating characteristic analysis was performed to calculate the area under the curve, which indicates the average sensitivity of variables and its 95% confidence interval are reported for each assessed parameter. The appropriate cut-off value indicating the sum of the highest sensitivity and specificity was calculated for the most predictive variable. The p value considered statistically significant was < 0.05. Results When comparing the postoperative and preoperative parameters of the main groups, it was determined that the NLR, MLR, and PLR values of both groups increased in the postoperative period, whereas the CA-125 value decreased. In a similar comparison within the subgroups, it was determined that NLR and PLR increased in all three groups in the postoperative period. MLR was found to increase in the stage 3–4 endometriosis and benign ovarian cyst groups. CA-125 decreased in the stage 3–4 endometriosis and benign ovarian cyst groups. RDW > 13.5, PLR > 123.4 and CA-125 > 35 were determined as the cut-off value to predict endometriosis. Conclusion During the follow-ups, we revealed that CA-125 still maintains its effectiveness. There is a lack of existing literature that directly compares hematological inflammatory parameters before and after treatment for endometriosis.https://doi.org/10.1186/s12905-025-03890-1CA-125EndometriosisNeutrophil to lymphocyte ratioPlatelet to lymphocyte ratio |
| spellingShingle | Onur Yavuz Asli Akdoner Kadir Alper Mankan Ufuk Atlihan Begum Ertan Mehmet Guney The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study BMC Women's Health CA-125 Endometriosis Neutrophil to lymphocyte ratio Platelet to lymphocyte ratio |
| title | The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study |
| title_full | The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study |
| title_fullStr | The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study |
| title_full_unstemmed | The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study |
| title_short | The comparison of hematological inflammatory parameters before and after surgery in women with endometriosis: retrospective cohort study |
| title_sort | comparison of hematological inflammatory parameters before and after surgery in women with endometriosis retrospective cohort study |
| topic | CA-125 Endometriosis Neutrophil to lymphocyte ratio Platelet to lymphocyte ratio |
| url | https://doi.org/10.1186/s12905-025-03890-1 |
| work_keys_str_mv | AT onuryavuz thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT asliakdoner thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT kadiralpermankan thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT ufukatlihan thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT begumertan thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT mehmetguney thecomparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT onuryavuz comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT asliakdoner comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT kadiralpermankan comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT ufukatlihan comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT begumertan comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy AT mehmetguney comparisonofhematologicalinflammatoryparametersbeforeandaftersurgeryinwomenwithendometriosisretrospectivecohortstudy |