How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications
AIM: It was aimed to investigate the epidemiological and antimicrobial resistance changes in enterococcal bacteremia over the years and the risk factors for mortality. It is intended to be a guide in patient follow-up and treatment. Backgraund: Enterococci are found in the intestine and can cause ba...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524002984 |
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| author | Nuran Sarı Nurefşan Tuba Kurt Özlem Kurt Azap |
| author_facet | Nuran Sarı Nurefşan Tuba Kurt Özlem Kurt Azap |
| author_sort | Nuran Sarı |
| collection | DOAJ |
| description | AIM: It was aimed to investigate the epidemiological and antimicrobial resistance changes in enterococcal bacteremia over the years and the risk factors for mortality. It is intended to be a guide in patient follow-up and treatment. Backgraund: Enterococci are found in the intestine and can cause bacteremia, endocarditis, and urinary tract infections. Bacteremias can have a complicated course and be fatal. METHODS: Between January 2020 and June 2024, Enterococcus species grown in blood cultures, interventions, comorbidities, resistance status, risk factors, and mortality were investigated retrospectively. RESULTS: Enterococcal bacteremia was detected in 237 patients. 220 (50.6%) of the patients were women. The average age of the patients was 69.2±15.87 (minimum 21, maximum 99). Enterococcus faecium was the most frequently detected agent (56.1%) (Figure 1). Antimicrobial resistance, presence of pneumonia, sepsis, mechanical ventilation, and concomitant COVID-19 were found to be significantly higher in mortal patients (p<0.05). Endocarditis was present in 11 patients, abscess was present in 20 patients, and spondylodiscitis was present in 3 patients. Enterococus faecium was not found to be higher in men, in the presence of immunosuppression, hospitalization in the last 3 months, and presence of an intrabdominal focus. Additionally, resistance to vancomycin (22%) ampicillin (%91) gentamicin (%62), imipenem (80%) and teicoplanin (19%) is significantly higher (p<0.05) (Table 1). 182 (76.8%) patients died. CONCLUSION: It should not be forgotten that enterococcal bacteremias have a high mortality rate and may have a complicated course. It should be kept in mind that antibiotic resistance is high in E. faceium. |
| format | Article |
| id | doaj-art-b219f160aba442e994a2c6cdbae8f35d |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-b219f160aba442e994a2c6cdbae8f35d2025-08-20T02:53:21ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-01393810.1016/j.jgar.2024.10.121How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complicationsNuran Sarı0Nurefşan Tuba Kurt1Özlem Kurt Azap2Department of Infectious Disease and Clinical Microbiology, Baskent Unıversty, Ankara, TurkeyDepartment of Infectious Disease and Clinical Microbiology, Baskent Unıversty, Ankara, TurkeyDepartment of Infectious Disease and Clinical Microbiology, Baskent Unıversty, Ankara, TurkeyAIM: It was aimed to investigate the epidemiological and antimicrobial resistance changes in enterococcal bacteremia over the years and the risk factors for mortality. It is intended to be a guide in patient follow-up and treatment. Backgraund: Enterococci are found in the intestine and can cause bacteremia, endocarditis, and urinary tract infections. Bacteremias can have a complicated course and be fatal. METHODS: Between January 2020 and June 2024, Enterococcus species grown in blood cultures, interventions, comorbidities, resistance status, risk factors, and mortality were investigated retrospectively. RESULTS: Enterococcal bacteremia was detected in 237 patients. 220 (50.6%) of the patients were women. The average age of the patients was 69.2±15.87 (minimum 21, maximum 99). Enterococcus faecium was the most frequently detected agent (56.1%) (Figure 1). Antimicrobial resistance, presence of pneumonia, sepsis, mechanical ventilation, and concomitant COVID-19 were found to be significantly higher in mortal patients (p<0.05). Endocarditis was present in 11 patients, abscess was present in 20 patients, and spondylodiscitis was present in 3 patients. Enterococus faecium was not found to be higher in men, in the presence of immunosuppression, hospitalization in the last 3 months, and presence of an intrabdominal focus. Additionally, resistance to vancomycin (22%) ampicillin (%91) gentamicin (%62), imipenem (80%) and teicoplanin (19%) is significantly higher (p<0.05) (Table 1). 182 (76.8%) patients died. CONCLUSION: It should not be forgotten that enterococcal bacteremias have a high mortality rate and may have a complicated course. It should be kept in mind that antibiotic resistance is high in E. faceium.http://www.sciencedirect.com/science/article/pii/S2213716524002984Enterococcusbacteremiasurvey |
| spellingShingle | Nuran Sarı Nurefşan Tuba Kurt Özlem Kurt Azap How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications Journal of Global Antimicrobial Resistance Enterococcus bacteremia survey |
| title | How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications |
| title_full | How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications |
| title_fullStr | How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications |
| title_full_unstemmed | How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications |
| title_short | How have Enterococcal bacteremias progressed in the last 5 years? Epidemiology, resistance to antimicrobials, risk factors, complications |
| title_sort | how have enterococcal bacteremias progressed in the last 5 years epidemiology resistance to antimicrobials risk factors complications |
| topic | Enterococcus bacteremia survey |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524002984 |
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