A pediatric case of dupilumab-induced pustular psoriasis
Aim: Dupilumab is a novel treatment agent for moderate to severe atopic dermatitis (AD) with few adverse effects. Drug-induced psoriasiform lesions are rare.Methods: We report a 4-year-old boy with AD who developed pustular psoriasis during treatment with dupilumab.Results: Pustular psoriasis appear...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2333016 |
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| author | Nan Dang Huiwen Zheng Yunqing Ren |
| author_facet | Nan Dang Huiwen Zheng Yunqing Ren |
| author_sort | Nan Dang |
| collection | DOAJ |
| description | Aim: Dupilumab is a novel treatment agent for moderate to severe atopic dermatitis (AD) with few adverse effects. Drug-induced psoriasiform lesions are rare.Methods: We report a 4-year-old boy with AD who developed pustular psoriasis during treatment with dupilumab.Results: Pustular psoriasis appeared within 1 week of treatment and worsened in the second week. After stopping dupilumab administration, topical corticosteroids (desonide and mometasone furoate creams) and oral desloratadine without relief. Pustular psoriasis was confirmed by pathological examination, and thiamphenicol was administered. After 2 weeks of treatment, the lesions nearly resolved without recurrence in 1-year follow-up.Conclusions: Dupilumab-induced pustular psoriasis is rare in children. |
| format | Article |
| id | doaj-art-b211a749937b43e6a9152f23610bdfc2 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-b211a749937b43e6a9152f23610bdfc22025-08-20T02:49:32ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2333016A pediatric case of dupilumab-induced pustular psoriasisNan Dang0Huiwen Zheng1Yunqing Ren2Department of Dermatology, Children’s Hospital of Zhejiang University School of Medicine, HangzhouDepartment of Dermatology, Children’s Hospital of Zhejiang University School of Medicine, HangzhouDepartment of Dermatology, Children’s Hospital of Zhejiang University School of Medicine, HangzhouAim: Dupilumab is a novel treatment agent for moderate to severe atopic dermatitis (AD) with few adverse effects. Drug-induced psoriasiform lesions are rare.Methods: We report a 4-year-old boy with AD who developed pustular psoriasis during treatment with dupilumab.Results: Pustular psoriasis appeared within 1 week of treatment and worsened in the second week. After stopping dupilumab administration, topical corticosteroids (desonide and mometasone furoate creams) and oral desloratadine without relief. Pustular psoriasis was confirmed by pathological examination, and thiamphenicol was administered. After 2 weeks of treatment, the lesions nearly resolved without recurrence in 1-year follow-up.Conclusions: Dupilumab-induced pustular psoriasis is rare in children.https://www.tandfonline.com/doi/10.1080/09546634.2024.2333016Atopic dermatitisdupilumabchildpustular psoriasis |
| spellingShingle | Nan Dang Huiwen Zheng Yunqing Ren A pediatric case of dupilumab-induced pustular psoriasis Journal of Dermatological Treatment Atopic dermatitis dupilumab child pustular psoriasis |
| title | A pediatric case of dupilumab-induced pustular psoriasis |
| title_full | A pediatric case of dupilumab-induced pustular psoriasis |
| title_fullStr | A pediatric case of dupilumab-induced pustular psoriasis |
| title_full_unstemmed | A pediatric case of dupilumab-induced pustular psoriasis |
| title_short | A pediatric case of dupilumab-induced pustular psoriasis |
| title_sort | pediatric case of dupilumab induced pustular psoriasis |
| topic | Atopic dermatitis dupilumab child pustular psoriasis |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2333016 |
| work_keys_str_mv | AT nandang apediatriccaseofdupilumabinducedpustularpsoriasis AT huiwenzheng apediatriccaseofdupilumabinducedpustularpsoriasis AT yunqingren apediatriccaseofdupilumabinducedpustularpsoriasis AT nandang pediatriccaseofdupilumabinducedpustularpsoriasis AT huiwenzheng pediatriccaseofdupilumabinducedpustularpsoriasis AT yunqingren pediatriccaseofdupilumabinducedpustularpsoriasis |