INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING
Aim. To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors fo...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2014-06-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/50 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850028272593666048 |
|---|---|
| author | A. S. Kruglikova I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Plokhova V. S. Pykhtina E. V. Dudinskaya O. Yu. Isaykina N. V. Sharashkina I. N. Ozerova V. A. Vygodin N. V. Gomyranova |
| author_facet | A. S. Kruglikova I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Plokhova V. S. Pykhtina E. V. Dudinskaya O. Yu. Isaykina N. V. Sharashkina I. N. Ozerova V. A. Vygodin N. V. Gomyranova |
| author_sort | A. S. Kruglikova |
| collection | DOAJ |
| description | Aim. To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors for cardiovascular diseases (smoking, arterial hypertension, obesity, dyslipidemia, fasting hyperglycemia). The telomere length and telomerase activity was measured by polymerase chain reaction. The thickness of intima-media complex (TIMC) and presence of atherosclerotic plaques (ASP) were measured by duplex scanning of right and left carotid arteries. Pulse wave velocity (PWV) was measured by applanation tonometry. Biochemical tests done by standard.Results. PWV significantly correlated with age, body mass index, glycosilated hemoglobin level, fasting glycemia and telomere length. Presence of ASP and increased TIMC significantly correlated with age, body mass index, arterial hypertension, dyslipidemia. Conclusion. Increase of arterial wall stiffness and subclinical atherosclerotic disease have different causes. The level of PWV more linked with carbohydrate metabolism disorder, and TIMC and ASP are linked with lipid disorders. |
| format | Article |
| id | doaj-art-b210ce139bcd4841a06b75770a0a9546 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-b210ce139bcd4841a06b75770a0a95462025-08-20T02:59:52Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252014-06-01133111710.15829/1728-8800-2014-3-11-1750INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGINGA. S. Kruglikova0I. D. Strajesko1O. N. Tkacheva2D. U. Akasheva3E. V. Plokhova4V. S. Pykhtina5E. V. Dudinskaya6O. Yu. Isaykina7N. V. Sharashkina8I. N. Ozerova9V. A. Vygodin10N. V. Gomyranova11FSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaFSBH State Research Centre for Preventive Medicine of the Ministry of Health. Moscow, RussiaAim. To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors for cardiovascular diseases (smoking, arterial hypertension, obesity, dyslipidemia, fasting hyperglycemia). The telomere length and telomerase activity was measured by polymerase chain reaction. The thickness of intima-media complex (TIMC) and presence of atherosclerotic plaques (ASP) were measured by duplex scanning of right and left carotid arteries. Pulse wave velocity (PWV) was measured by applanation tonometry. Biochemical tests done by standard.Results. PWV significantly correlated with age, body mass index, glycosilated hemoglobin level, fasting glycemia and telomere length. Presence of ASP and increased TIMC significantly correlated with age, body mass index, arterial hypertension, dyslipidemia. Conclusion. Increase of arterial wall stiffness and subclinical atherosclerotic disease have different causes. The level of PWV more linked with carbohydrate metabolism disorder, and TIMC and ASP are linked with lipid disorders.https://cardiovascular.elpub.ru/jour/article/view/50vascular agingarterial stiffnesstelomerescardiovascular risk factorscarbohydrate metabolismlipid metabolism |
| spellingShingle | A. S. Kruglikova I. D. Strajesko O. N. Tkacheva D. U. Akasheva E. V. Plokhova V. S. Pykhtina E. V. Dudinskaya O. Yu. Isaykina N. V. Sharashkina I. N. Ozerova V. A. Vygodin N. V. Gomyranova INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING Кардиоваскулярная терапия и профилактика vascular aging arterial stiffness telomeres cardiovascular risk factors carbohydrate metabolism lipid metabolism |
| title | INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING |
| title_full | INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING |
| title_fullStr | INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING |
| title_full_unstemmed | INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING |
| title_short | INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING |
| title_sort | interrelation between cardiovascular risk factors and telomere biology with the signs of vascular aging |
| topic | vascular aging arterial stiffness telomeres cardiovascular risk factors carbohydrate metabolism lipid metabolism |
| url | https://cardiovascular.elpub.ru/jour/article/view/50 |
| work_keys_str_mv | AT askruglikova interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT idstrajesko interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT ontkacheva interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT duakasheva interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT evplokhova interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT vspykhtina interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT evdudinskaya interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT oyuisaykina interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT nvsharashkina interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT inozerova interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT vavygodin interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging AT nvgomyranova interrelationbetweencardiovascularriskfactorsandtelomerebiologywiththesignsofvascularaging |