Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy
Abstract Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as a revolutionary tool to su...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03236-x |
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| author | Jiayi Zhang Fang Wang Zhaogang Sun Jun Ye Hongqian Chu |
| author_facet | Jiayi Zhang Fang Wang Zhaogang Sun Jun Ye Hongqian Chu |
| author_sort | Jiayi Zhang |
| collection | DOAJ |
| description | Abstract Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as a revolutionary tool to surmount these obstacles and amplify the potency of immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function in cancer immunotherapy, including acting as a nanocarrier to deliver immunotherapeutic agents, as a photothermal agent to improve the efficacy of immunotherapy through photothermal therapy, as a nanozyme to regulate tumor microenvironment, and as an iron donor to induce immune events related to ferroptosis and tumor-associated macrophages polarization. This review focuses on the advances and applications of PBNPs in cancer immunotherapy. First, the biomedical functions of PBNPs are introduced. Then, based on the immune function of PBNPs, we systematically reviewed the multidimensional application of PBNPs in cancer immunotherapy. Finally, the challenges and future developments of PBNPs-based cancer immunotherapy are highlighted. Graphical abstract |
| format | Article |
| id | doaj-art-b20759d9ea2b4788be99772e78e54d2e |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-b20759d9ea2b4788be99772e78e54d2e2025-08-20T01:57:27ZengBMCJournal of Nanobiotechnology1477-31552025-03-0123113510.1186/s12951-025-03236-xMultidimensional applications of prussian blue-based nanoparticles in cancer immunotherapyJiayi Zhang0Fang Wang1Zhaogang Sun2Jun Ye3Hongqian Chu4Translational Medicine Center, Beijing Chest Hospital, Capital Medical UniversityTranslational Medicine Center, Beijing Chest Hospital, Capital Medical UniversityTranslational Medicine Center, Beijing Chest Hospital, Capital Medical UniversityState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical CollegeTranslational Medicine Center, Beijing Chest Hospital, Capital Medical UniversityAbstract Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as a revolutionary tool to surmount these obstacles and amplify the potency of immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function in cancer immunotherapy, including acting as a nanocarrier to deliver immunotherapeutic agents, as a photothermal agent to improve the efficacy of immunotherapy through photothermal therapy, as a nanozyme to regulate tumor microenvironment, and as an iron donor to induce immune events related to ferroptosis and tumor-associated macrophages polarization. This review focuses on the advances and applications of PBNPs in cancer immunotherapy. First, the biomedical functions of PBNPs are introduced. Then, based on the immune function of PBNPs, we systematically reviewed the multidimensional application of PBNPs in cancer immunotherapy. Finally, the challenges and future developments of PBNPs-based cancer immunotherapy are highlighted. Graphical abstracthttps://doi.org/10.1186/s12951-025-03236-xPrussian blueNanoparticlesPhotothermal therapyNanozymeFerroptosisCancer immunotherapy |
| spellingShingle | Jiayi Zhang Fang Wang Zhaogang Sun Jun Ye Hongqian Chu Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy Journal of Nanobiotechnology Prussian blue Nanoparticles Photothermal therapy Nanozyme Ferroptosis Cancer immunotherapy |
| title | Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy |
| title_full | Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy |
| title_fullStr | Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy |
| title_full_unstemmed | Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy |
| title_short | Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy |
| title_sort | multidimensional applications of prussian blue based nanoparticles in cancer immunotherapy |
| topic | Prussian blue Nanoparticles Photothermal therapy Nanozyme Ferroptosis Cancer immunotherapy |
| url | https://doi.org/10.1186/s12951-025-03236-x |
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