An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter
Abstract Understanding proton relaxation in the brain’s white matter remains an active field of magnetic resonance imaging research. Models of varying complexity have been proposed to link measurements to tissue composition/microstructure, in particular myelination. Although the presence of multiple...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87362-4 |
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| author | Niklas Wallstein André Pampel Roland Müller Carsten Jäger Markus Morawski Harald E. Möller |
| author_facet | Niklas Wallstein André Pampel Roland Müller Carsten Jäger Markus Morawski Harald E. Möller |
| author_sort | Niklas Wallstein |
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| description | Abstract Understanding proton relaxation in the brain’s white matter remains an active field of magnetic resonance imaging research. Models of varying complexity have been proposed to link measurements to tissue composition/microstructure, in particular myelination. Although the presence of multiple aqueous and nonaqueous proton pools is well established experimentally, so-called “quantitative MRI” is usually based on simpler models due to the large number of model parameters. In this work, a comprehensive set of parameters characterizing a four-pool model is obtained. A piece of fixed porcine spinal-cord WM was investigated at 3 T and temperatures between 21 and 35 °C. Measurements included a wide range of preparations of the spin system in combination with long echo trains to achieve sensitivity to all model parameters. The results allow the extraction of all intrinsic relaxation and exchange rates as well as assigning them to specific dynamic processes involving tissue water. A critical assessment indicates that simpler models often lack specificity to myelin. |
| format | Article |
| id | doaj-art-b204c88688464fd78e062a9e53190b0b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b204c88688464fd78e062a9e53190b0b2025-02-09T12:32:54ZengNature PortfolioScientific Reports2045-23222025-02-0115111910.1038/s41598-025-87362-4An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matterNiklas Wallstein0André Pampel1Roland Müller2Carsten Jäger3Markus Morawski4Harald E. Möller5NMR Methods and Development Group, Max Planck Institute for Human Cognitive and Brain SciencesNMR Methods and Development Group, Max Planck Institute for Human Cognitive and Brain SciencesNMR Methods and Development Group, Max Planck Institute for Human Cognitive and Brain SciencesDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain SciencesMedical Faculty, Paul Flechsig Institute – Centre of Neuropathology and Brain Research, Leipzig UniversityNMR Methods and Development Group, Max Planck Institute for Human Cognitive and Brain SciencesAbstract Understanding proton relaxation in the brain’s white matter remains an active field of magnetic resonance imaging research. Models of varying complexity have been proposed to link measurements to tissue composition/microstructure, in particular myelination. Although the presence of multiple aqueous and nonaqueous proton pools is well established experimentally, so-called “quantitative MRI” is usually based on simpler models due to the large number of model parameters. In this work, a comprehensive set of parameters characterizing a four-pool model is obtained. A piece of fixed porcine spinal-cord WM was investigated at 3 T and temperatures between 21 and 35 °C. Measurements included a wide range of preparations of the spin system in combination with long echo trains to achieve sensitivity to all model parameters. The results allow the extraction of all intrinsic relaxation and exchange rates as well as assigning them to specific dynamic processes involving tissue water. A critical assessment indicates that simpler models often lack specificity to myelin.https://doi.org/10.1038/s41598-025-87362-4Four-pool modelLongitudinal relaxationMagnetization transferMyelinationTransverse relaxationWhite matter |
| spellingShingle | Niklas Wallstein André Pampel Roland Müller Carsten Jäger Markus Morawski Harald E. Möller An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter Scientific Reports Four-pool model Longitudinal relaxation Magnetization transfer Myelination Transverse relaxation White matter |
| title | An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| title_full | An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| title_fullStr | An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| title_full_unstemmed | An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| title_short | An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| title_sort | unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter |
| topic | Four-pool model Longitudinal relaxation Magnetization transfer Myelination Transverse relaxation White matter |
| url | https://doi.org/10.1038/s41598-025-87362-4 |
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