Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients
Abstract Background Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. It seriously affects the growth and development of child patients. Methods NR3C1 rs41423247 and FAAH rs324420 polymorphisms were detected by the polymerase chain reaction in 105 ped...
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BMC
2025-02-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-01870-7 |
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| author | Hongli Wang Chu Li Qian Li Ning Li Huiling Qin |
| author_facet | Hongli Wang Chu Li Qian Li Ning Li Huiling Qin |
| author_sort | Hongli Wang |
| collection | DOAJ |
| description | Abstract Background Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. It seriously affects the growth and development of child patients. Methods NR3C1 rs41423247 and FAAH rs324420 polymorphisms were detected by the polymerase chain reaction in 105 pediatric epilepsy patients. Patients were divided into the good response group and the poor response group after anti-seizure medications (ASMs) treatment. According to the results of the liver function test (LFT), patients were divided into the no LFT disturbance group and the LFT disturbance group. Hardy–Weinberg balance was applied to analyze the population representation. The correlations were calculated by logistic regression analysis. Results NR3C1 rs41423247 genotype and allele frequencies differed significantly between good response and poor response groups, while FAAH rs324420 did not. The CG genotype and C allele of NR3C1 rs41423247 were associated with good drug response, and the association was also detected in the dominant model. In addition, polymorphisms in NR3C1 and FAAH were not associated with liver damage induced by epilepsy medication. Conclusion The polymorphism of NR3C1 rs41423247 might influence the drug response of epilepsy children. |
| format | Article |
| id | doaj-art-b1fe3b1f47c04ec180a37def224cfe71 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-b1fe3b1f47c04ec180a37def224cfe712025-02-09T12:48:09ZengBMCItalian Journal of Pediatrics1824-72882025-02-015111810.1186/s13052-025-01870-7Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patientsHongli Wang0Chu Li1Qian Li2Ning Li3Huiling Qin4Department of Paediatric, Affiliated Hospital of Chengdu UniversityThe First Clinical Medical School, Guangzhou University of Chinese MedicineDepartment of Paediatric, Dongying People’s HospitalDepartment of Surgery, Guangrao County Traditional Chinese Medicine HospitalDepartment of Rehabilitation Medicine, The Affiliated Hospital of Youjiang Medical University for NationalitiesAbstract Background Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. It seriously affects the growth and development of child patients. Methods NR3C1 rs41423247 and FAAH rs324420 polymorphisms were detected by the polymerase chain reaction in 105 pediatric epilepsy patients. Patients were divided into the good response group and the poor response group after anti-seizure medications (ASMs) treatment. According to the results of the liver function test (LFT), patients were divided into the no LFT disturbance group and the LFT disturbance group. Hardy–Weinberg balance was applied to analyze the population representation. The correlations were calculated by logistic regression analysis. Results NR3C1 rs41423247 genotype and allele frequencies differed significantly between good response and poor response groups, while FAAH rs324420 did not. The CG genotype and C allele of NR3C1 rs41423247 were associated with good drug response, and the association was also detected in the dominant model. In addition, polymorphisms in NR3C1 and FAAH were not associated with liver damage induced by epilepsy medication. Conclusion The polymorphism of NR3C1 rs41423247 might influence the drug response of epilepsy children.https://doi.org/10.1186/s13052-025-01870-7NR3C1 rs41423247FAAH rs324420Drug responseEpilepsyLiver dysfunction |
| spellingShingle | Hongli Wang Chu Li Qian Li Ning Li Huiling Qin Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients Italian Journal of Pediatrics NR3C1 rs41423247 FAAH rs324420 Drug response Epilepsy Liver dysfunction |
| title | Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients |
| title_full | Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients |
| title_fullStr | Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients |
| title_full_unstemmed | Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients |
| title_short | Drug response is related to NR3C1 and FAAH polymorphism in Chinese pediatric epilepsy patients |
| title_sort | drug response is related to nr3c1 and faah polymorphism in chinese pediatric epilepsy patients |
| topic | NR3C1 rs41423247 FAAH rs324420 Drug response Epilepsy Liver dysfunction |
| url | https://doi.org/10.1186/s13052-025-01870-7 |
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