Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare inflammatory demyelinating disorder affecting the central nervous system and optic nerve, thus leading to optic neuritis as the most common manifestation. We report a case of a 29-year-old female who presented with sud...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Clinical Ophthalmology and Research |
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| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_157_24 |
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| author | Shweta Singh Sanjiv Kumar Gupta Shaffi Chopra |
| author_facet | Shweta Singh Sanjiv Kumar Gupta Shaffi Chopra |
| author_sort | Shweta Singh |
| collection | DOAJ |
| description | Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare inflammatory demyelinating disorder affecting the central nervous system and optic nerve, thus leading to optic neuritis as the most common manifestation. We report a case of a 29-year-old female who presented with sudden loss of vision in her right eye, followed by left eye, accompanied by headache, mild periorbital pain, hiccups, and nausea, without any weakness or relevant medical history. She was diagnosed with MOG antibody-associated demyelinating optic neuritis based on MRI and blood investigations. The patient was given intravenous methylprednisolone (IVMP) but showed no improvement. Subsequently, retrobulbar dexamethasone injection was administered, leading to significant and rapid vision recovery. This case suggests that retrobulbar dexamethasone injections can be an effective adjunct therapy for early and prompt recovery in patients with MOG antibody-associated optic neuritis when systemic treatments fail. |
| format | Article |
| id | doaj-art-b1f73bdf76e840c38fbe89e16601cb80 |
| institution | OA Journals |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-b1f73bdf76e840c38fbe89e16601cb802025-08-20T02:32:04ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-04-0113223023210.4103/jcor.jcor_157_24Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literatureShweta SinghSanjiv Kumar GuptaShaffi ChopraMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare inflammatory demyelinating disorder affecting the central nervous system and optic nerve, thus leading to optic neuritis as the most common manifestation. We report a case of a 29-year-old female who presented with sudden loss of vision in her right eye, followed by left eye, accompanied by headache, mild periorbital pain, hiccups, and nausea, without any weakness or relevant medical history. She was diagnosed with MOG antibody-associated demyelinating optic neuritis based on MRI and blood investigations. The patient was given intravenous methylprednisolone (IVMP) but showed no improvement. Subsequently, retrobulbar dexamethasone injection was administered, leading to significant and rapid vision recovery. This case suggests that retrobulbar dexamethasone injections can be an effective adjunct therapy for early and prompt recovery in patients with MOG antibody-associated optic neuritis when systemic treatments fail.https://journals.lww.com/10.4103/jcor.jcor_157_24central nervous systemintravenous methylprednisolonemyelin oligodendrocyte glycoprotein |
| spellingShingle | Shweta Singh Sanjiv Kumar Gupta Shaffi Chopra Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature Journal of Clinical Ophthalmology and Research central nervous system intravenous methylprednisolone myelin oligodendrocyte glycoprotein |
| title | Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature |
| title_full | Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature |
| title_fullStr | Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature |
| title_full_unstemmed | Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature |
| title_short | Targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody-associated rare optic neuritis: Clinical outcome and review literature |
| title_sort | targeted steroid delivery for myelin oligodendrocyte glycoprotein antibody associated rare optic neuritis clinical outcome and review literature |
| topic | central nervous system intravenous methylprednisolone myelin oligodendrocyte glycoprotein |
| url | https://journals.lww.com/10.4103/jcor.jcor_157_24 |
| work_keys_str_mv | AT shwetasingh targetedsteroiddeliveryformyelinoligodendrocyteglycoproteinantibodyassociatedrareopticneuritisclinicaloutcomeandreviewliterature AT sanjivkumargupta targetedsteroiddeliveryformyelinoligodendrocyteglycoproteinantibodyassociatedrareopticneuritisclinicaloutcomeandreviewliterature AT shaffichopra targetedsteroiddeliveryformyelinoligodendrocyteglycoproteinantibodyassociatedrareopticneuritisclinicaloutcomeandreviewliterature |