Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility

Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility

Abstract Oocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)‐binding protein in Xenopus, mouse, and human oocytes and early embryos prior to zygotic genome activation, plays a key role in transl...

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Main Authors: Weijie Wang, Jing Guo, Juanzi Shi, Qun Li, Biaobang Chen, Zhiqi Pan, Ronggui Qu, Jing Fu, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Wenjing Wang, Lin Zhao, Qiaoli Li, Lin He, Xiaoxi Sun, Qing Sang, Ge Lin, Lei Wang
Format: Article
Language:English
Published: Springer Nature 2023-04-01
Series:EMBO Molecular Medicine
Subjects:
female infertility
Mos‐MAPK
mRNA translational activation
oocyte maturation arrest
PABPC1L
Online Access:https://doi.org/10.15252/emmm.202217177
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