Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis
Objective: to estimate the time course of bone mineral density (BMD) changes during 4-year rituximab (RTM) therapy in postmenopausal women with rheumatoid arthritis (RA).Subjects and methods. Seventy-nine postmenopausal women with a valid diagnosis of RA were followed up. According to the basic ther...
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| Language: | Russian |
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IMA-PRESS LLC
2015-09-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/633 |
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| author | T. A. Raskina M. V. Koroleva I. S. Dydykina O. S. Malyshenko G. A. Pintova |
| author_facet | T. A. Raskina M. V. Koroleva I. S. Dydykina O. S. Malyshenko G. A. Pintova |
| author_sort | T. A. Raskina |
| collection | DOAJ |
| description | Objective: to estimate the time course of bone mineral density (BMD) changes during 4-year rituximab (RTM) therapy in postmenopausal women with rheumatoid arthritis (RA).Subjects and methods. Seventy-nine postmenopausal women with a valid diagnosis of RA were followed up. According to the basic therapy option, all the patients were allocated into two groups: 1) 44 patients who received combination therapy with RTM and methotrexate (MT); 2) 35 patients who had MT monotherapy. BMD was estimated by dual-energy X-ray absorptiometry using an Excell XR-46 stationary dualenergy X-ray bone densitometer (Norland, USA).Results. There was a statistically significant increase in femoral neck BMD and T score as compared to the baseline values in the RTM group after 3 years of follow-up. The MT monotherapy group showed no statistically significant densitometric changes in the femoral neck. The similar positive BMD changes were observed 4 years following RTM and MT therapy.Conclusion. Following 2 therapy cycles, femoral neck BMD parameters were noted to be stabilized in the patients with RA. After 3 therapy cycles, there was a positive densitometric change that remained by the fourth therapy cycle. |
| format | Article |
| id | doaj-art-b1efbaea63514590bbefd9b2e3a7f733 |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-b1efbaea63514590bbefd9b2e3a7f7332025-08-20T03:59:57ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2015-09-0193162010.14412/1996-7012-2015-3-16-201927Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritisT. A. Raskina0M. V. Koroleva1I. S. Dydykina2O. S. Malyshenko3G. A. Pintova4Kemerovo State Medical Academy, Ministry of Health of RussiaKemerovo State Medical Academy, Ministry of Health of RussiaV.A. Nasonova Research Institute of RheumatologyKemerovo State Medical Academy, Ministry of Health of RussiaResearch Institute for Complex Problems of Hygiene and Occupational DiseasesObjective: to estimate the time course of bone mineral density (BMD) changes during 4-year rituximab (RTM) therapy in postmenopausal women with rheumatoid arthritis (RA).Subjects and methods. Seventy-nine postmenopausal women with a valid diagnosis of RA were followed up. According to the basic therapy option, all the patients were allocated into two groups: 1) 44 patients who received combination therapy with RTM and methotrexate (MT); 2) 35 patients who had MT monotherapy. BMD was estimated by dual-energy X-ray absorptiometry using an Excell XR-46 stationary dualenergy X-ray bone densitometer (Norland, USA).Results. There was a statistically significant increase in femoral neck BMD and T score as compared to the baseline values in the RTM group after 3 years of follow-up. The MT monotherapy group showed no statistically significant densitometric changes in the femoral neck. The similar positive BMD changes were observed 4 years following RTM and MT therapy.Conclusion. Following 2 therapy cycles, femoral neck BMD parameters were noted to be stabilized in the patients with RA. After 3 therapy cycles, there was a positive densitometric change that remained by the fourth therapy cycle.https://mrj.ima-press.net/mrj/article/view/633postmenopausal womenrheumatoid arthritisosteoporosisbone mineral densityrituximab |
| spellingShingle | T. A. Raskina M. V. Koroleva I. S. Dydykina O. S. Malyshenko G. A. Pintova Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis Современная ревматология postmenopausal women rheumatoid arthritis osteoporosis bone mineral density rituximab |
| title | Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| title_full | Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| title_fullStr | Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| title_full_unstemmed | Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| title_short | Time course of bone mineral density changes during 4-year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| title_sort | time course of bone mineral density changes during 4 year rituximab therapy in postmenopausal women with rheumatoid arthritis |
| topic | postmenopausal women rheumatoid arthritis osteoporosis bone mineral density rituximab |
| url | https://mrj.ima-press.net/mrj/article/view/633 |
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