Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review

Ovarian hyperstimulation syndrome (OHSS) is a rare complication often associated with superovulation cycles for fertility treatment. This report presents a case of spontaneous OHSS (sOHSS) during a frozen-thawed embryo transfer (FET) cycle, an event rarely documented in the literature. We describe h...

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Main Authors: Nguyen-Tuong Ho, Thi-Thanh-Thao Pham, Shu-Huei Kao, Chii-Ruey Tzeng
Format: Article
Language:English
Published: World Scientific Publishing 2024-12-01
Series:Fertility & Reproduction
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Online Access:https://www.worldscientific.com/doi/10.1142/S2661318224720010
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author Nguyen-Tuong Ho
Thi-Thanh-Thao Pham
Shu-Huei Kao
Chii-Ruey Tzeng
author_facet Nguyen-Tuong Ho
Thi-Thanh-Thao Pham
Shu-Huei Kao
Chii-Ruey Tzeng
author_sort Nguyen-Tuong Ho
collection DOAJ
description Ovarian hyperstimulation syndrome (OHSS) is a rare complication often associated with superovulation cycles for fertility treatment. This report presents a case of spontaneous OHSS (sOHSS) during a frozen-thawed embryo transfer (FET) cycle, an event rarely documented in the literature. We describe herein the case of a 37-year-old nulligravida woman who presented with features suggestive of polycystic ovarian syndrome (PCOS), underwent FET using an artificial endometrial preparation protocol, and was transferred with two frozen-thawed blastocysts, which finally resulted in a diamniotic twin pregnancy. At the 12th week of gestation, the patient developed sOHSS with hyperthyroidism, which was successfully managed conservatively, and favorable outcomes were observed at delivery. This case contributes to the limited literature on sOHSS in FET cycles, reinforcing the importance of tailored monitoring and conservative management for optimal outcomes in such infertile patients.
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publishDate 2024-12-01
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series Fertility & Reproduction
spelling doaj-art-b1ee7930876e45d485670ef2e3c302d22025-08-20T02:58:18ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742024-12-01060417618210.1142/S2661318224720010Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature ReviewNguyen-Tuong Ho0Thi-Thanh-Thao Pham1Shu-Huei Kao2Chii-Ruey Tzeng3Taipei Fertility Center, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, VietnamProgram in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanTaipei Fertility Center, Taipei, TaiwanOvarian hyperstimulation syndrome (OHSS) is a rare complication often associated with superovulation cycles for fertility treatment. This report presents a case of spontaneous OHSS (sOHSS) during a frozen-thawed embryo transfer (FET) cycle, an event rarely documented in the literature. We describe herein the case of a 37-year-old nulligravida woman who presented with features suggestive of polycystic ovarian syndrome (PCOS), underwent FET using an artificial endometrial preparation protocol, and was transferred with two frozen-thawed blastocysts, which finally resulted in a diamniotic twin pregnancy. At the 12th week of gestation, the patient developed sOHSS with hyperthyroidism, which was successfully managed conservatively, and favorable outcomes were observed at delivery. This case contributes to the limited literature on sOHSS in FET cycles, reinforcing the importance of tailored monitoring and conservative management for optimal outcomes in such infertile patients.https://www.worldscientific.com/doi/10.1142/S2661318224720010Spontaneous Ovarian Hyperstimulation SyndromeFrozen-Thawed Embryo TransferPolycystic Ovarian Syndrome
spellingShingle Nguyen-Tuong Ho
Thi-Thanh-Thao Pham
Shu-Huei Kao
Chii-Ruey Tzeng
Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
Fertility & Reproduction
Spontaneous Ovarian Hyperstimulation Syndrome
Frozen-Thawed Embryo Transfer
Polycystic Ovarian Syndrome
title Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
title_full Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
title_fullStr Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
title_full_unstemmed Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
title_short Characteristics of Ovarian Hyperstimulation Syndrome During Pregnancy Resulting from Frozen-Thawed Embryo Transfer: A Case Report and Literature Review
title_sort characteristics of ovarian hyperstimulation syndrome during pregnancy resulting from frozen thawed embryo transfer a case report and literature review
topic Spontaneous Ovarian Hyperstimulation Syndrome
Frozen-Thawed Embryo Transfer
Polycystic Ovarian Syndrome
url https://www.worldscientific.com/doi/10.1142/S2661318224720010
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