Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial
Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic str...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2017/1391843 |
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| author | Ilko L. Maier Katharina Schregel André Karch Mark Weber-Krueger Rafael T. Mikolajczyk Raoul Stahrenberg Klaus Gröschel Mathias Bähr Michael Knauth Marios-Nikos Psychogios Rolf Wachter Jan Liman |
| author_facet | Ilko L. Maier Katharina Schregel André Karch Mark Weber-Krueger Rafael T. Mikolajczyk Raoul Stahrenberg Klaus Gröschel Mathias Bähr Michael Knauth Marios-Nikos Psychogios Rolf Wachter Jan Liman |
| author_sort | Ilko L. Maier |
| collection | DOAJ |
| description | Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. The aim of our study was to evaluate the association between embolic stroke patterns, ESUS, and the new diagnosis of AF. Methods. Stroke etiology and imaging characteristics from patients included in the Find-AF study were obtained. Embolic stroke patterns in CT- or MR-imaging were correlated with the diagnosis of ESUS as well as the short- (on baseline ECG and during 7-day Holter) and long-term (12-month follow-up) diagnosis of AF. Results. From 281 patients included in the Find-AF study, 127 (45.2%) patients with ischemic lesions detected in CT or MRI were included. 26 (20.5%) of these patients had ESUS. At least one embolic stroke pattern was detected in 67 (52.7%) patients. Embolic stroke patterns were not associated with ESUS (OR 1.57, 0.65–3.79, p=0.317), the short-term (OR 0.64, 0.26–1.58, p=0.327) or long-term diagnosis of AF (OR 0.72, 0.31–1.68, p=0.448). Conclusions. This secondary data analysis of the Find-AF study could not provide evidence for an association between embolic stroke patterns, ESUS, and the new diagnosis of AF. |
| format | Article |
| id | doaj-art-b1ecbfde69a247dea7950696931ab21f |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-b1ecbfde69a247dea7950696931ab21f2025-08-20T03:39:18ZengWileyStroke Research and Treatment2090-81052042-00562017-01-01201710.1155/2017/13918431391843Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF TrialIlko L. Maier0Katharina Schregel1André Karch2Mark Weber-Krueger3Rafael T. Mikolajczyk4Raoul Stahrenberg5Klaus Gröschel6Mathias Bähr7Michael Knauth8Marios-Nikos Psychogios9Rolf Wachter10Jan Liman11Department of Neurology, University Medicine Göttingen, Göttingen, GermanyDepartment of Neuroradiology, University Medicine Göttingen, Göttingen, GermanyResearch Group Epidemiological and Statistical Methods (ESME), Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Cardiology and Pneumology, University Medicine Göttingen, Göttingen, GermanyResearch Group Epidemiological and Statistical Methods (ESME), Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Cardiology and Pneumology, University Medicine Göttingen, Göttingen, GermanyDepartment of Neurology, University Medicine Mainz, Mainz, GermanyDepartment of Neurology, University Medicine Göttingen, Göttingen, GermanyDepartment of Neuroradiology, University Medicine Göttingen, Göttingen, GermanyDepartment of Neuroradiology, University Medicine Göttingen, Göttingen, GermanyDepartment of Cardiology and Pneumology, University Medicine Göttingen, Göttingen, GermanyDepartment of Neurology, University Medicine Göttingen, Göttingen, GermanyBackground. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. The aim of our study was to evaluate the association between embolic stroke patterns, ESUS, and the new diagnosis of AF. Methods. Stroke etiology and imaging characteristics from patients included in the Find-AF study were obtained. Embolic stroke patterns in CT- or MR-imaging were correlated with the diagnosis of ESUS as well as the short- (on baseline ECG and during 7-day Holter) and long-term (12-month follow-up) diagnosis of AF. Results. From 281 patients included in the Find-AF study, 127 (45.2%) patients with ischemic lesions detected in CT or MRI were included. 26 (20.5%) of these patients had ESUS. At least one embolic stroke pattern was detected in 67 (52.7%) patients. Embolic stroke patterns were not associated with ESUS (OR 1.57, 0.65–3.79, p=0.317), the short-term (OR 0.64, 0.26–1.58, p=0.327) or long-term diagnosis of AF (OR 0.72, 0.31–1.68, p=0.448). Conclusions. This secondary data analysis of the Find-AF study could not provide evidence for an association between embolic stroke patterns, ESUS, and the new diagnosis of AF.http://dx.doi.org/10.1155/2017/1391843 |
| spellingShingle | Ilko L. Maier Katharina Schregel André Karch Mark Weber-Krueger Rafael T. Mikolajczyk Raoul Stahrenberg Klaus Gröschel Mathias Bähr Michael Knauth Marios-Nikos Psychogios Rolf Wachter Jan Liman Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial Stroke Research and Treatment |
| title | Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial |
| title_full | Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial |
| title_fullStr | Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial |
| title_full_unstemmed | Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial |
| title_short | Association between Embolic Stroke Patterns, ESUS Etiology, and New Diagnosis of Atrial Fibrillation: A Secondary Data Analysis of the Find-AF Trial |
| title_sort | association between embolic stroke patterns esus etiology and new diagnosis of atrial fibrillation a secondary data analysis of the find af trial |
| url | http://dx.doi.org/10.1155/2017/1391843 |
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