Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis
Osteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals. During normal bone development, chondrocyte hypertrophy is a natural physiological process. However, in the progression of...
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MDPI AG
2025-01-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/1/77 |
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| author | Da-Long Dong Guang-Zhen Jin |
| author_facet | Da-Long Dong Guang-Zhen Jin |
| author_sort | Da-Long Dong |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals. During normal bone development, chondrocyte hypertrophy is a natural physiological process. However, in the progression of OA, chondrocyte hypertrophy becomes one of its key pathological features. Although there is no definitive evidence to date confirming that chondrocyte hypertrophy is the direct cause of OA, substantial experimental data indicate that it plays an important role in the disease’s pathogenesis. In this review, we first explore the mechanisms underlying chondrocyte hypertrophy in OA and offer new insights. We then propose strategies for inhibiting chondrocyte hypertrophy from the perspectives of targeting signaling pathways and tissue engineering, ultimately envisioning the future prospects of OA treatment. |
| format | Article |
| id | doaj-art-b1ebcc452d8d49bca7132ff49e20e2fa |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-b1ebcc452d8d49bca7132ff49e20e2fa2025-01-24T13:23:11ZengMDPI AGBioengineering2306-53542025-01-011217710.3390/bioengineering12010077Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of OsteoarthritisDa-Long Dong0Guang-Zhen Jin1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of KoreaInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of KoreaOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals. During normal bone development, chondrocyte hypertrophy is a natural physiological process. However, in the progression of OA, chondrocyte hypertrophy becomes one of its key pathological features. Although there is no definitive evidence to date confirming that chondrocyte hypertrophy is the direct cause of OA, substantial experimental data indicate that it plays an important role in the disease’s pathogenesis. In this review, we first explore the mechanisms underlying chondrocyte hypertrophy in OA and offer new insights. We then propose strategies for inhibiting chondrocyte hypertrophy from the perspectives of targeting signaling pathways and tissue engineering, ultimately envisioning the future prospects of OA treatment.https://www.mdpi.com/2306-5354/12/1/77osteoarthritischondrocyte hypertrophysignaling pathwayssmall molecule compoundstissue engineering |
| spellingShingle | Da-Long Dong Guang-Zhen Jin Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis Bioengineering osteoarthritis chondrocyte hypertrophy signaling pathways small molecule compounds tissue engineering |
| title | Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis |
| title_full | Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis |
| title_fullStr | Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis |
| title_full_unstemmed | Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis |
| title_short | Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis |
| title_sort | targeting chondrocyte hypertrophy as strategies for the treatment of osteoarthritis |
| topic | osteoarthritis chondrocyte hypertrophy signaling pathways small molecule compounds tissue engineering |
| url | https://www.mdpi.com/2306-5354/12/1/77 |
| work_keys_str_mv | AT dalongdong targetingchondrocytehypertrophyasstrategiesforthetreatmentofosteoarthritis AT guangzhenjin targetingchondrocytehypertrophyasstrategiesforthetreatmentofosteoarthritis |