The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model
Abstract Background The intricate interplay between stemness markers and cell death pathways significantly influences the pathophysiology of cervical cancer. SOX2, a pivotal regulator of stem cell pluripotency, has recently been implicated in the modulation of ferroptosis, a specialized form of iron...
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-05973-2 |
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| author | Shenping Liu Zhi Wei Huiqing Ding |
| author_facet | Shenping Liu Zhi Wei Huiqing Ding |
| author_sort | Shenping Liu |
| collection | DOAJ |
| description | Abstract Background The intricate interplay between stemness markers and cell death pathways significantly influences the pathophysiology of cervical cancer. SOX2, a pivotal regulator of stem cell pluripotency, has recently been implicated in the modulation of ferroptosis, a specialized form of iron-dependent cell death, in cancer dynamics. This study delineates the role of SOX2 in the ferroptotic landscape of cervical carcinoma. Objective To delineate the association between SOX2 expression and ferroptosis in cervical cancer and develop a robust, SOX2-centric model for predicting prognosis and enhancing personalized treatment. Methods A multidimensional approach integrating advanced bioinformatics, comprehensive molecular profiling, and state-of-the-art machine learning algorithms was employed to assess SOX2 expression patterns and their correlation with ferroptosis marker expression patterns in cervical cancer tissues. A prognostic model incorporating the expression levels of SOX2 and ferroptosis indicators was meticulously constructed. Results This investigation revealed a profound and intricate correlation between SOX2 expression and ferroptotic processes in cervical cancer, substantiated by robust molecular evidence. The developed predictive model based on SOX2 expression exhibited superior prognostic accuracy and may guide therapeutic decision-making. Conclusion This study underscores the critical role of SOX2 in orchestrating the ferroptosis pathway in cervical cancer and presents a novel prognostic framework. The SOX2-centric predictive model represents a significant advancement in prognosis evaluation, offering a gateway to personalized treatment for gynaecologic cancers. |
| format | Article |
| id | doaj-art-b1e729ac7b9a4be0b671b01f1f482483 |
| institution | DOAJ |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-b1e729ac7b9a4be0b671b01f1f4824832025-08-20T02:57:39ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-11-011501212010.1007/s00432-024-05973-2The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive modelShenping Liu0Zhi Wei1Huiqing Ding2The First Affiliated Hospital of Ningbo UniversityThe First Affiliated Hospital of Ningbo UniversityThe First Affiliated Hospital of Ningbo UniversityAbstract Background The intricate interplay between stemness markers and cell death pathways significantly influences the pathophysiology of cervical cancer. SOX2, a pivotal regulator of stem cell pluripotency, has recently been implicated in the modulation of ferroptosis, a specialized form of iron-dependent cell death, in cancer dynamics. This study delineates the role of SOX2 in the ferroptotic landscape of cervical carcinoma. Objective To delineate the association between SOX2 expression and ferroptosis in cervical cancer and develop a robust, SOX2-centric model for predicting prognosis and enhancing personalized treatment. Methods A multidimensional approach integrating advanced bioinformatics, comprehensive molecular profiling, and state-of-the-art machine learning algorithms was employed to assess SOX2 expression patterns and their correlation with ferroptosis marker expression patterns in cervical cancer tissues. A prognostic model incorporating the expression levels of SOX2 and ferroptosis indicators was meticulously constructed. Results This investigation revealed a profound and intricate correlation between SOX2 expression and ferroptotic processes in cervical cancer, substantiated by robust molecular evidence. The developed predictive model based on SOX2 expression exhibited superior prognostic accuracy and may guide therapeutic decision-making. Conclusion This study underscores the critical role of SOX2 in orchestrating the ferroptosis pathway in cervical cancer and presents a novel prognostic framework. The SOX2-centric predictive model represents a significant advancement in prognosis evaluation, offering a gateway to personalized treatment for gynaecologic cancers.https://doi.org/10.1007/s00432-024-05973-2SOX2 GeneCervical CancerFerroptosisBioinformatics |
| spellingShingle | Shenping Liu Zhi Wei Huiqing Ding The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model Journal of Cancer Research and Clinical Oncology SOX2 Gene Cervical Cancer Ferroptosis Bioinformatics |
| title | The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model |
| title_full | The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model |
| title_fullStr | The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model |
| title_full_unstemmed | The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model |
| title_short | The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model |
| title_sort | role of the sox2 gene in cervical cancer focus on ferroptosis and construction of a predictive model |
| topic | SOX2 Gene Cervical Cancer Ferroptosis Bioinformatics |
| url | https://doi.org/10.1007/s00432-024-05973-2 |
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