Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021
Abstract Bladder cancer is the most prevalent malignancies in the urinary system. This study was designed to investigate the trends of bladder cancer in China and differences compared with various Socio-demographic index (SDI) regions. Data from the Global Burden of Disease (GBD) 2021 database were...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-08634-7 |
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| author | Xiaosheng Chen Hanbin Guo Sizhe Cao Jieming Lin Peidong Huang Wei Zhang Huirong Lin Xinji Li Hui Zhang |
| author_facet | Xiaosheng Chen Hanbin Guo Sizhe Cao Jieming Lin Peidong Huang Wei Zhang Huirong Lin Xinji Li Hui Zhang |
| author_sort | Xiaosheng Chen |
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| description | Abstract Bladder cancer is the most prevalent malignancies in the urinary system. This study was designed to investigate the trends of bladder cancer in China and differences compared with various Socio-demographic index (SDI) regions. Data from the Global Burden of Disease (GBD) 2021 database were utilized to evaluate metrics associated with bladder cancer, including age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years rate (DALY) (ASDR). All analyses, including joinpoint regression, age-period-cohort, decomposition, spearman correlation, frontier and cross-country inequality, and Bayesian age-period-cohort, were utilized. In 2021, bladder cancer posed a significant health burden in China, with 570,636 total cases, including 463,364 males. The disease burden increased from low to high SDI regions, with China falling in the middle to high-middle SDI range. Apart from China, middle SDI and low-middle SDI regions, the ASIR of all other SDI regions showed a decreasing trend. The ASPR of bladder cancer increase globally, particularly in China and middle SDI region. Meanwhile, the ASMR and ASDR declined in China and all SDI regions. The age-period-cohort analysis showed that period and cohort effects influenced the ASIR and ASPR differently across China and each SDI region. Population growth was the primary driver of increases in these metrics. Projections suggest continued increases in ASIR, ASPR, and ASDR for both genders in China through 2036. The burden of bladder cancer is significant in China and varies across SDI regions, highlighting the link between socioeconomic development and disease burden. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b1e57eeece0e4b9aaed3b92ff65041ae2025-08-20T04:01:23ZengNature PortfolioScientific Reports2045-23222025-07-0115111510.1038/s41598-025-08634-7Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021Xiaosheng Chen0Hanbin Guo1Sizhe Cao2Jieming Lin3Peidong Huang4Wei Zhang5Huirong Lin6Xinji Li7Hui Zhang8Department of Urology, Jieyang People’s HospitalDepartment of Gastrointestinal-2 and Vascular Surgery, The Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Urology, Shantou Central HospitalDepartment of Operating Room, Jieyang People’s HospitalDepartment of Urology, Jieyang People’s HospitalDepartment of Urology, Jieyang People’s HospitalDepartment of Urology, Jieyang People’s HospitalDepartment of Urology, Jieyang People’s HospitalDepartment of Urology, Jieyang People’s HospitalAbstract Bladder cancer is the most prevalent malignancies in the urinary system. This study was designed to investigate the trends of bladder cancer in China and differences compared with various Socio-demographic index (SDI) regions. Data from the Global Burden of Disease (GBD) 2021 database were utilized to evaluate metrics associated with bladder cancer, including age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years rate (DALY) (ASDR). All analyses, including joinpoint regression, age-period-cohort, decomposition, spearman correlation, frontier and cross-country inequality, and Bayesian age-period-cohort, were utilized. In 2021, bladder cancer posed a significant health burden in China, with 570,636 total cases, including 463,364 males. The disease burden increased from low to high SDI regions, with China falling in the middle to high-middle SDI range. Apart from China, middle SDI and low-middle SDI regions, the ASIR of all other SDI regions showed a decreasing trend. The ASPR of bladder cancer increase globally, particularly in China and middle SDI region. Meanwhile, the ASMR and ASDR declined in China and all SDI regions. The age-period-cohort analysis showed that period and cohort effects influenced the ASIR and ASPR differently across China and each SDI region. Population growth was the primary driver of increases in these metrics. Projections suggest continued increases in ASIR, ASPR, and ASDR for both genders in China through 2036. The burden of bladder cancer is significant in China and varies across SDI regions, highlighting the link between socioeconomic development and disease burden.https://doi.org/10.1038/s41598-025-08634-7Bladder cancerGlobal burden of diseaseSocio-demographic indexAge-period-cohort analysisDecomposition analysis |
| spellingShingle | Xiaosheng Chen Hanbin Guo Sizhe Cao Jieming Lin Peidong Huang Wei Zhang Huirong Lin Xinji Li Hui Zhang Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 Scientific Reports Bladder cancer Global burden of disease Socio-demographic index Age-period-cohort analysis Decomposition analysis |
| title | Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 |
| title_full | Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 |
| title_fullStr | Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 |
| title_full_unstemmed | Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 |
| title_short | Disease burden of bladder cancer in China and the different SDI regions over the world from 1990 to 2021 |
| title_sort | disease burden of bladder cancer in china and the different sdi regions over the world from 1990 to 2021 |
| topic | Bladder cancer Global burden of disease Socio-demographic index Age-period-cohort analysis Decomposition analysis |
| url | https://doi.org/10.1038/s41598-025-08634-7 |
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