Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature
We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter statu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/431819 |
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| author | Mohamed H. Khattab Ariel E. Marciscano Simon S. Lo Michael Lim John J. Laterra Lawrence R. Kleinberg Kristin J. Redmond |
| author_facet | Mohamed H. Khattab Ariel E. Marciscano Simon S. Lo Michael Lim John J. Laterra Lawrence R. Kleinberg Kristin J. Redmond |
| author_sort | Mohamed H. Khattab |
| collection | DOAJ |
| description | We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab. |
| format | Article |
| id | doaj-art-b1e4f2f4d9ef4e6da76da58178a23322 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-b1e4f2f4d9ef4e6da76da58178a233222025-08-20T03:39:25ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/431819431819Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the LiteratureMohamed H. Khattab0Ariel E. Marciscano1Simon S. Lo2Michael Lim3John J. Laterra4Lawrence R. Kleinberg5Kristin J. Redmond6Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USADepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USADepartment of Radiation Oncology, Case Western Reserve University, University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USADepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USADepartment of Neurology/Neuro-Oncology, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287, USADepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USADepartment of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USAWe present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.http://dx.doi.org/10.1155/2015/431819 |
| spellingShingle | Mohamed H. Khattab Ariel E. Marciscano Simon S. Lo Michael Lim John J. Laterra Lawrence R. Kleinberg Kristin J. Redmond Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature |
| title_full | Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature |
| title_fullStr | Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature |
| title_full_unstemmed | Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature |
| title_short | Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature |
| title_sort | antiangiogenic therapies and extracranial metastasis in glioblastoma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2015/431819 |
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