Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation.
<h4>Background</h4>Non-tuberculous mycobacteria (NTM) are pulmonary pathogens with increasing incidence and prevalence worldwide, with people with cystic fibrosis (pwCF) traditionally considered at high risk of disease development. The imaging assessment of NTM-pulmonary disease (NTM-PD)...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325347 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424051392479232 |
|---|---|
| author | Ieuan Edward Shepherd Evans Timothy Baird Charles S Haworth Christopher Johnson Helen Barker Uta Hill Dorothy Grogono Odiri Eneje Nicholas Screaton Andres Floto |
| author_facet | Ieuan Edward Shepherd Evans Timothy Baird Charles S Haworth Christopher Johnson Helen Barker Uta Hill Dorothy Grogono Odiri Eneje Nicholas Screaton Andres Floto |
| author_sort | Ieuan Edward Shepherd Evans |
| collection | DOAJ |
| description | <h4>Background</h4>Non-tuberculous mycobacteria (NTM) are pulmonary pathogens with increasing incidence and prevalence worldwide, with people with cystic fibrosis (pwCF) traditionally considered at high risk of disease development. The imaging assessment of NTM-pulmonary disease (NTM-PD) relies heavily on high-resolution computed tomography (HRCT). However, due to lengthy treatment regimens and the need for long-term follow-up, serial HRCT's result in progressive exposure to ionizing radiation; a particular concern in younger people.<h4>Methods</h4>We performed a retrospective cohort study of patients who had undergone serial thoracic magnetic resonance imaging (tMRI) scans to monitor NTM-PD as a novel tool to image the lung with a view to creating an algorithm for the utility of tMRI in the management of NTM-PD.<h4>Results</h4>Thirty-six patients, of which twenty-four had a diagnosis of CF, with suspected or confirmed NTM-PD underwent serial tMRI between 1st January 2013 and 30th June 2018. A total of 117 serial tMRI's were performed (mean number per patient 3.25; range 2-6). The associated clinical impact that each serial MRI had on management, deemed as the utility of tMRI, found that all tMRI's were classified as aiding management with 60 (51.3%) altering management. tMRI's were more likely to alter management in the non-CF cohort than the CF cohort (69.4% vs. 43.2%). No imaging-related adverse events were reported across the 117 tMRI's.<h4>Conclusion</h4>This study highlights that tMRI may hold promise as a monitoring tool in NTM-PD and should be prospectively evaluated in the monitoring of individuals with NTM-PD. |
| format | Article |
| id | doaj-art-b1e0ca643ec245d0868e75094abf3a01 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b1e0ca643ec245d0868e75094abf3a012025-08-20T03:30:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032534710.1371/journal.pone.0325347Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation.Ieuan Edward Shepherd EvansTimothy BairdCharles S HaworthChristopher JohnsonHelen BarkerUta HillDorothy GrogonoOdiri EnejeNicholas ScreatonAndres Floto<h4>Background</h4>Non-tuberculous mycobacteria (NTM) are pulmonary pathogens with increasing incidence and prevalence worldwide, with people with cystic fibrosis (pwCF) traditionally considered at high risk of disease development. The imaging assessment of NTM-pulmonary disease (NTM-PD) relies heavily on high-resolution computed tomography (HRCT). However, due to lengthy treatment regimens and the need for long-term follow-up, serial HRCT's result in progressive exposure to ionizing radiation; a particular concern in younger people.<h4>Methods</h4>We performed a retrospective cohort study of patients who had undergone serial thoracic magnetic resonance imaging (tMRI) scans to monitor NTM-PD as a novel tool to image the lung with a view to creating an algorithm for the utility of tMRI in the management of NTM-PD.<h4>Results</h4>Thirty-six patients, of which twenty-four had a diagnosis of CF, with suspected or confirmed NTM-PD underwent serial tMRI between 1st January 2013 and 30th June 2018. A total of 117 serial tMRI's were performed (mean number per patient 3.25; range 2-6). The associated clinical impact that each serial MRI had on management, deemed as the utility of tMRI, found that all tMRI's were classified as aiding management with 60 (51.3%) altering management. tMRI's were more likely to alter management in the non-CF cohort than the CF cohort (69.4% vs. 43.2%). No imaging-related adverse events were reported across the 117 tMRI's.<h4>Conclusion</h4>This study highlights that tMRI may hold promise as a monitoring tool in NTM-PD and should be prospectively evaluated in the monitoring of individuals with NTM-PD.https://doi.org/10.1371/journal.pone.0325347 |
| spellingShingle | Ieuan Edward Shepherd Evans Timothy Baird Charles S Haworth Christopher Johnson Helen Barker Uta Hill Dorothy Grogono Odiri Eneje Nicholas Screaton Andres Floto Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. PLoS ONE |
| title | Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. |
| title_full | Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. |
| title_fullStr | Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. |
| title_full_unstemmed | Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. |
| title_short | Thoracic magnetic resonance imaging in non-tuberculous mycobacterial pulmonary disease: Characteristics and potential implementation. |
| title_sort | thoracic magnetic resonance imaging in non tuberculous mycobacterial pulmonary disease characteristics and potential implementation |
| url | https://doi.org/10.1371/journal.pone.0325347 |
| work_keys_str_mv | AT ieuanedwardshepherdevans thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT timothybaird thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT charlesshaworth thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT christopherjohnson thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT helenbarker thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT utahill thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT dorothygrogono thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT odirieneje thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT nicholasscreaton thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation AT andresfloto thoracicmagneticresonanceimaginginnontuberculousmycobacterialpulmonarydiseasecharacteristicsandpotentialimplementation |