Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B

Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B

BackgroundDysregulated and excessive inflammatory reactions can lead to tissue damage, which is the underlying cause of most human diseases. Menisoxoisoaporphine A (MA), a novel oxoisoaporphine alkaloid, was obtained from Menispermi Rhizoma, a traditional Chinese medicinal herb used in the treatment...

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Bibliographic Details
Main Authors: Xin Qiao, Xiaojuan Cao, Shuang Xu, Cunlin Wang, Rui Guo, Xiaojuan Yao, Qiong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
menisoxoisoaporphine A
inflammation
PDE4B
cAMP-PKA
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1505116/full
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