Primary Antimicrobial Susceptibility Changes in Children with Helicobacter pylori Infection over 13 Years in Northern Italy
The eradication therapy of Helicobacter pylori (H. pylori) infection is still a challenge for gastroenterologists. One of the main causes of failure in H. pylori eradication is the antibiotic resistance mainly to clarithromycin. Culture from biopsies is maybe the most used method among the antimicro...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/717349 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The eradication therapy of Helicobacter pylori (H. pylori) infection is still a challenge for
gastroenterologists. One of the main causes of failure in H. pylori eradication is the antibiotic
resistance mainly to clarithromycin. Culture from biopsies is maybe the most used method among
the antimicrobial susceptibility techniques. In this study, we compared the antimicrobial
susceptibility changes in children with H. pylori infection over 13 years and we confirmed that
clarithromycin resistance has been increased (16% versus 26%) though with no statistically signficant
value. Therefore, clarithromycin should not be used in empiric treatment of H. pylori eradication
therapy in children, but its use should be limited only to children with known antimicrobial
susceptibility. On the other hand, metronidazole resistance has decreased over this time period in
statistically significant manner (56% versus 33%, p=0.014). Furthermore, ampicillin resistance has been confirmed to be very rare (3% versus 0%) in children with H. pylori infection. In conclusion, in H. pylori infection, if we do not
know the antibiotic susceptibility of patients, we should recommend an eradication therapy based
on the local distribution of antibiotic resistance rates trying to limit the therapeutic failures. |
|---|---|
| ISSN: | 1687-6121 1687-630X |