MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy

MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy

Abstract Metallothioneins (MTs) are a class of cysteine-rich proteins that actively participate in the cellular defense against free radicals. However, owing to the high heterogeneity among different MTs, comprehensive investigations are needed to determine the biological activities and distribution...

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Bibliographic Details
Main Authors: Yamin Xing, Guangyuan Li, Ganggang Li, Jixuan Xu, Ting Zhang, Mengxue Li, Chunxiao Gao, Miaoran Fu, Pengyuan Zheng, Xiufeng Chu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Metallothionein
Gastric cancer
p53
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-91319-y
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