Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system
Abstract This study evaluates a novel three-dimensional (3D) quality assurance (QA) device, the Mobile Phosphor Probe (MPP), for pretreatment dose verification in Gamma Knife (GK) stereotactic radiosurgery. The MPP system consists of a cylindrical phantom with a phosphor screen, an imaging unit with...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-04925-1 |
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| author | Minsik Lee KyoungJoon Yoon Jun-Bong Shin BongHyo Lee Jungwon Kwak DoHeui Lee |
| author_facet | Minsik Lee KyoungJoon Yoon Jun-Bong Shin BongHyo Lee Jungwon Kwak DoHeui Lee |
| author_sort | Minsik Lee |
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| description | Abstract This study evaluates a novel three-dimensional (3D) quality assurance (QA) device, the Mobile Phosphor Probe (MPP), for pretreatment dose verification in Gamma Knife (GK) stereotactic radiosurgery. The MPP system consists of a cylindrical phantom with a phosphor screen, an imaging unit with a charge-coupled device (CCD) camera, and a motorized driving unit. Dose distributions are reconstructed from images using a lookup table, which correlates CCD pixel optical density with dose values, calibrated against EBT3 film readings. Results show that the full width at half maximum of normalized dose distributions between film and CCD were consistent within a 0.2 mm margin. A 3D dose distribution was constructed by stacking two-dimensional images obtained at 0.3 mm intervals over a ± 30 mm range in the superior-inferior direction. Validation was achieved by comparing the reconstructed 3D doses with planned distributions across multiple planes using gamma evaluation. All cases within the 20–80% isodose line (IDL) range achieved a 95% gamma passing rate under 2.0%/2.0 mm criteria, and the 1.0%/1.0 mm criteria were met at the 50% IDL in all dimensions. The MPP system demonstrates potential as an efficient patient-specific QA tool for GK radiosurgery, offering a streamlined alternative to traditional film dosimetry. |
| format | Article |
| id | doaj-art-b1d8bc6de75540ad8d6ed80d8bdc58ba |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b1d8bc6de75540ad8d6ed80d8bdc58ba2025-08-20T03:42:25ZengNature PortfolioScientific Reports2045-23222025-07-011511710.1038/s41598-025-04925-1Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe systemMinsik Lee0KyoungJoon Yoon1Jun-Bong Shin2BongHyo Lee3Jungwon Kwak4DoHeui Lee5Department of Radiation Oncology, Kangwon National University HospitalDepartment of Radiation Oncology, Asan Medical CenterDepartment of Radiation Oncology, Kangwon National University HospitalDepartment of Physics, Yeungnam UniversityDepartment of Radiation Oncology, Asan Medical CenterDepartment of Radiation Oncology, Asan Medical CenterAbstract This study evaluates a novel three-dimensional (3D) quality assurance (QA) device, the Mobile Phosphor Probe (MPP), for pretreatment dose verification in Gamma Knife (GK) stereotactic radiosurgery. The MPP system consists of a cylindrical phantom with a phosphor screen, an imaging unit with a charge-coupled device (CCD) camera, and a motorized driving unit. Dose distributions are reconstructed from images using a lookup table, which correlates CCD pixel optical density with dose values, calibrated against EBT3 film readings. Results show that the full width at half maximum of normalized dose distributions between film and CCD were consistent within a 0.2 mm margin. A 3D dose distribution was constructed by stacking two-dimensional images obtained at 0.3 mm intervals over a ± 30 mm range in the superior-inferior direction. Validation was achieved by comparing the reconstructed 3D doses with planned distributions across multiple planes using gamma evaluation. All cases within the 20–80% isodose line (IDL) range achieved a 95% gamma passing rate under 2.0%/2.0 mm criteria, and the 1.0%/1.0 mm criteria were met at the 50% IDL in all dimensions. The MPP system demonstrates potential as an efficient patient-specific QA tool for GK radiosurgery, offering a streamlined alternative to traditional film dosimetry.https://doi.org/10.1038/s41598-025-04925-1Gamma knife3D patient specific QARadiosurgeryMobile phosphor probe |
| spellingShingle | Minsik Lee KyoungJoon Yoon Jun-Bong Shin BongHyo Lee Jungwon Kwak DoHeui Lee Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system Scientific Reports Gamma knife 3D patient specific QA Radiosurgery Mobile phosphor probe |
| title | Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| title_full | Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| title_fullStr | Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| title_full_unstemmed | Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| title_short | Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| title_sort | feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system |
| topic | Gamma knife 3D patient specific QA Radiosurgery Mobile phosphor probe |
| url | https://doi.org/10.1038/s41598-025-04925-1 |
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