A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis
Nitric oxide (NO) is a key signaling molecule involved in cellular communication and plays a critical role in various biological processes. Given its dual role in the pathogenesis of endometriosis, we conducted a systematic literature review to explore its mechanisms further. Numerous studies have i...
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MDPI AG
2025-02-01
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| Series: | Antioxidants |
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| author | Seung Geun Yeo Yeon Ju Oh Jae Min Lee Sung Soo Kim Dong Choon Park |
| author_facet | Seung Geun Yeo Yeon Ju Oh Jae Min Lee Sung Soo Kim Dong Choon Park |
| author_sort | Seung Geun Yeo |
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| description | Nitric oxide (NO) is a key signaling molecule involved in cellular communication and plays a critical role in various biological processes. Given its dual role in the pathogenesis of endometriosis, we conducted a systematic literature review to explore its mechanisms further. Numerous studies have investigated the expression and role of NO in various diseases, including those in the field of gynecology. However, the expression and role of NO in endometriosis remain a topic of ongoing debate. Therefore, we conducted a comprehensive literature review using the Cochrane Library, EMBASE, Google Scholar, PubMed, and SCOPUS databases to evaluate the induction and role of NO in the pathogenesis of endometriosis. Of the 27 papers ultimately reviewed, 22 (81.4%) reported that NO contributes to the pathogenesis of endometriosis, 3 (11.1%) suggested that NO acts as a protective mechanism against endometriosis, and 2 studies (7.4%) found no association between NO and the pathogenesis of endometriosis. The expression and levels of NO in endometriosis were associated with pregnancy, infertility, menstruation, and pelvic pain. Research conducted on rats and mice demonstrated that NO, nNOS, eNOS, and iNOS play significant roles in the development of endometriosis. Most studies suggested that increased NO levels are associated with the pathogenesis of endometriosis. |
| format | Article |
| id | doaj-art-b1d42e06b9bf43c09cc7dfebe96e050a |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Antioxidants |
| spelling | doaj-art-b1d42e06b9bf43c09cc7dfebe96e050a2025-08-20T02:11:17ZengMDPI AGAntioxidants2076-39212025-02-0114324710.3390/antiox14030247A Narrative Review of the Expression and Role of Nitric Oxide in EndometriosisSeung Geun Yeo0Yeon Ju Oh1Jae Min Lee2Sung Soo Kim3Dong Choon Park4Department of Otorhinolaryngology—Head and Neck Surgery, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Medicine, College of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of KoreaDepartment of Otorhinolaryngology—Head and Neck Surgery, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Biochemistry and Molecular Biology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Obstetrics and Gynecology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaNitric oxide (NO) is a key signaling molecule involved in cellular communication and plays a critical role in various biological processes. Given its dual role in the pathogenesis of endometriosis, we conducted a systematic literature review to explore its mechanisms further. Numerous studies have investigated the expression and role of NO in various diseases, including those in the field of gynecology. However, the expression and role of NO in endometriosis remain a topic of ongoing debate. Therefore, we conducted a comprehensive literature review using the Cochrane Library, EMBASE, Google Scholar, PubMed, and SCOPUS databases to evaluate the induction and role of NO in the pathogenesis of endometriosis. Of the 27 papers ultimately reviewed, 22 (81.4%) reported that NO contributes to the pathogenesis of endometriosis, 3 (11.1%) suggested that NO acts as a protective mechanism against endometriosis, and 2 studies (7.4%) found no association between NO and the pathogenesis of endometriosis. The expression and levels of NO in endometriosis were associated with pregnancy, infertility, menstruation, and pelvic pain. Research conducted on rats and mice demonstrated that NO, nNOS, eNOS, and iNOS play significant roles in the development of endometriosis. Most studies suggested that increased NO levels are associated with the pathogenesis of endometriosis.https://www.mdpi.com/2076-3921/14/3/247endometriosisnitric oxide |
| spellingShingle | Seung Geun Yeo Yeon Ju Oh Jae Min Lee Sung Soo Kim Dong Choon Park A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis Antioxidants endometriosis nitric oxide |
| title | A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis |
| title_full | A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis |
| title_fullStr | A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis |
| title_full_unstemmed | A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis |
| title_short | A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis |
| title_sort | narrative review of the expression and role of nitric oxide in endometriosis |
| topic | endometriosis nitric oxide |
| url | https://www.mdpi.com/2076-3921/14/3/247 |
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