Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome

Plasmacytoid urothelial carcinoma (PUC) is a newly recognized rare variant of urothelial carcinoma, which is now being increasingly diagnosed prospectively as well as by retrospective analysis of cases with a poor prognosis. Morphologically, these tumors simulate plasma cell neoplasms and pose a dia...

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Main Authors: Aparna Chenniappan, Norton S. Stephen, Bheemanathi H. Srinivas, Sreerag K. Sreenivasan, Ramkumar Govindarajalou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
Online Access:https://journals.lww.com/10.4103/ijpm.ijpm_840_21
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author Aparna Chenniappan
Norton S. Stephen
Bheemanathi H. Srinivas
Sreerag K. Sreenivasan
Ramkumar Govindarajalou
author_facet Aparna Chenniappan
Norton S. Stephen
Bheemanathi H. Srinivas
Sreerag K. Sreenivasan
Ramkumar Govindarajalou
author_sort Aparna Chenniappan
collection DOAJ
description Plasmacytoid urothelial carcinoma (PUC) is a newly recognized rare variant of urothelial carcinoma, which is now being increasingly diagnosed prospectively as well as by retrospective analysis of cases with a poor prognosis. Morphologically, these tumors simulate plasma cell neoplasms and pose a diagnostic challenge. Identifying this variant is essential in two aspects: therapy and prognosis. Here, we present a case who underwent multiple transurethral resection of bladder tumor (TURBT) procedures, each with a diagnosis of urothelial carcinoma, the plasmacytoid type which was confirmed on radical cystectomy, and after 1 year, the patient presented with duodenal metastasis. We discuss the morphological aspects of differentiating this tumor from variants of urothelial carcinoma and other tumors with a plasmacytoid appearance. Despite the recognition and aggressive treatment, the patient expires within 2 years of the first diagnosis of bladder carcinoma.
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institution Kabale University
issn 0377-4929
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language English
publishDate 2023-01-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Indian Journal of Pathology and Microbiology
spelling doaj-art-b1d0bf4cc0c24915be3da851c66bdc1c2025-01-22T15:13:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-01-0167117517710.4103/ijpm.ijpm_840_21Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcomeAparna ChenniappanNorton S. StephenBheemanathi H. SrinivasSreerag K. SreenivasanRamkumar GovindarajalouPlasmacytoid urothelial carcinoma (PUC) is a newly recognized rare variant of urothelial carcinoma, which is now being increasingly diagnosed prospectively as well as by retrospective analysis of cases with a poor prognosis. Morphologically, these tumors simulate plasma cell neoplasms and pose a diagnostic challenge. Identifying this variant is essential in two aspects: therapy and prognosis. Here, we present a case who underwent multiple transurethral resection of bladder tumor (TURBT) procedures, each with a diagnosis of urothelial carcinoma, the plasmacytoid type which was confirmed on radical cystectomy, and after 1 year, the patient presented with duodenal metastasis. We discuss the morphological aspects of differentiating this tumor from variants of urothelial carcinoma and other tumors with a plasmacytoid appearance. Despite the recognition and aggressive treatment, the patient expires within 2 years of the first diagnosis of bladder carcinoma.https://journals.lww.com/10.4103/ijpm.ijpm_840_21duodenal metastasisplasmacytoidurothelial carcinoma
spellingShingle Aparna Chenniappan
Norton S. Stephen
Bheemanathi H. Srinivas
Sreerag K. Sreenivasan
Ramkumar Govindarajalou
Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
Indian Journal of Pathology and Microbiology
duodenal metastasis
plasmacytoid
urothelial carcinoma
title Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
title_full Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
title_fullStr Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
title_full_unstemmed Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
title_short Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome
title_sort plasmacytoid urothelial carcinoma with duodenal metastasis a rare tumor with unusual site of metastasis with grim outcome
topic duodenal metastasis
plasmacytoid
urothelial carcinoma
url https://journals.lww.com/10.4103/ijpm.ijpm_840_21
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AT bheemanathihsrinivas plasmacytoidurothelialcarcinomawithduodenalmetastasisararetumorwithunusualsiteofmetastasiswithgrimoutcome
AT sreeragksreenivasan plasmacytoidurothelialcarcinomawithduodenalmetastasisararetumorwithunusualsiteofmetastasiswithgrimoutcome
AT ramkumargovindarajalou plasmacytoidurothelialcarcinomawithduodenalmetastasisararetumorwithunusualsiteofmetastasiswithgrimoutcome