Gut microbiota-driven neuroinflammation in Alzheimer’s disease: from mechanisms to therapeutic opportunities

Gut microbiota-driven neuroinflammation in Alzheimer’s disease: from mechanisms to therapeutic opportunities

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, tau hyperphosphorylation, and chronic neuroinflammation. While neuroinflammation—mediated by microglial and astrocyte activation—has long been considered a secondary response to Aβ pathol...

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Bibliographic Details
Main Authors: Wenhui Lei, Yiwen Cheng, Xia Liu, Jie Gao, Zhangcheng Zhu, Wenwen Ding, Xiaocui Xu, Yating Li, Zongxin Ling, Ruilai Jiang, Xiaoying Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Alzheimer’s disease
butyrate
fecal microbiota transplantation
neuroinflammation
gut microbiota
microbiota-gut-brain axis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582119/full
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