Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021
Objectives: Avian influenza (AI) H5N6 has replaced H5N1 as the predominant strain, and the increasing number of cases and complex recombination patterns pose significant threats to human health. Methods: The data were collected on human cases of AI H5N6 from the National Surveillance of Notifiable I...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122400359X |
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| author | Fuyin Bi Weitao He Ning Kang Hang Huang Huafeng Chen Zhenli Liang Yu Ju Jun Zeng Jing Wang |
| author_facet | Fuyin Bi Weitao He Ning Kang Hang Huang Huafeng Chen Zhenli Liang Yu Ju Jun Zeng Jing Wang |
| author_sort | Fuyin Bi |
| collection | DOAJ |
| description | Objectives: Avian influenza (AI) H5N6 has replaced H5N1 as the predominant strain, and the increasing number of cases and complex recombination patterns pose significant threats to human health. Methods: The data were collected on human cases of AI H5N6 from the National Surveillance of Notifiable Infectious Disease Programme in Guangxi and used MEGA software to conduct phylogenetic analysis with published reference strains obtained from the GISAID database. Results: Between January 1 and December 31, 2021, 11 cases of human AI H5N6 infection were reported in Guangxi. All HA genes belonged to clade 2.3.4.4, with only one virus belonging to 2.3.4.4h and the remaining viruses falling into 2.3.4.4b. Phylogenetic analysis of the genes was conducted, and some substitutions were detected in the HA gene, M1 protein, and NS1 protein. A close relationship between Guangxi viruses and AI viruses of poultry origin has been observed. Conclusion: Given the contamination of live poultry markets and backyard poultry, AI H5N6 variants and genotypes will continuously emerge; therefore, enhancing surveillance is crucial for pandemic preparedness. |
| format | Article |
| id | doaj-art-b1cd17da8a034463818d9abf134164a8 |
| institution | OA Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-b1cd17da8a034463818d9abf134164a82025-08-20T02:36:59ZengElsevierInternational Journal of Infectious Diseases1201-97122025-01-0115010728810.1016/j.ijid.2024.107288Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021Fuyin Bi0Weitao He1Ning Kang2Hang Huang3Huafeng Chen4Zhenli Liang5Yu Ju6Jun Zeng7Jing Wang8Institute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, China; Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, China; Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, China; Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, ChinaInstitute of Acute Communicable Disease Prevention and Control, Guangxi Center for Disease Prevention and Control, Nanning, Guangxi, China; Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Center for Disease Control and Prevention, Nanning, China; Corresponding author: Jing Wang, Guangxi Center for Disease Prevention and Control, 18 Jinzhou Road, Nanning, Guangxi 530028, China.Objectives: Avian influenza (AI) H5N6 has replaced H5N1 as the predominant strain, and the increasing number of cases and complex recombination patterns pose significant threats to human health. Methods: The data were collected on human cases of AI H5N6 from the National Surveillance of Notifiable Infectious Disease Programme in Guangxi and used MEGA software to conduct phylogenetic analysis with published reference strains obtained from the GISAID database. Results: Between January 1 and December 31, 2021, 11 cases of human AI H5N6 infection were reported in Guangxi. All HA genes belonged to clade 2.3.4.4, with only one virus belonging to 2.3.4.4h and the remaining viruses falling into 2.3.4.4b. Phylogenetic analysis of the genes was conducted, and some substitutions were detected in the HA gene, M1 protein, and NS1 protein. A close relationship between Guangxi viruses and AI viruses of poultry origin has been observed. Conclusion: Given the contamination of live poultry markets and backyard poultry, AI H5N6 variants and genotypes will continuously emerge; therefore, enhancing surveillance is crucial for pandemic preparedness.http://www.sciencedirect.com/science/article/pii/S120197122400359XAvian influenzaAI H5N6EpidemicPhylogenetic analysis |
| spellingShingle | Fuyin Bi Weitao He Ning Kang Hang Huang Huafeng Chen Zhenli Liang Yu Ju Jun Zeng Jing Wang Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 International Journal of Infectious Diseases Avian influenza AI H5N6 Epidemic Phylogenetic analysis |
| title | Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 |
| title_full | Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 |
| title_fullStr | Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 |
| title_full_unstemmed | Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 |
| title_short | Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021 |
| title_sort | epidemiological and genetic characterization of human infection with avian influenza ai h5n6 virus in guangxi china 2021 |
| topic | Avian influenza AI H5N6 Epidemic Phylogenetic analysis |
| url | http://www.sciencedirect.com/science/article/pii/S120197122400359X |
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