Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation
We used a non-integrated reprogramming approach to establish a human induced pluripotent stem cell (hiPSC) line (INNDSUi011-A) from the skin fibroblasts of a 38-year-old female individual with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation. The cells obtained demonstrate key chara...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506125001576 |
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| author | Didi Shan Hongxu Wang Jianing Li Yu Wang Fuchen Liu |
| author_facet | Didi Shan Hongxu Wang Jianing Li Yu Wang Fuchen Liu |
| author_sort | Didi Shan |
| collection | DOAJ |
| description | We used a non-integrated reprogramming approach to establish a human induced pluripotent stem cell (hiPSC) line (INNDSUi011-A) from the skin fibroblasts of a 38-year-old female individual with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation. The cells obtained demonstrate key characteristics of embryonic stem cells, including the expression of specific pluripotency markers and the capacity to differentiate into the three germ layers in vitro. This iPSC cell line retains the patient’s genetic information, making it a valuable model for studying disease mechanisms and developing novel therapies. |
| format | Article |
| id | doaj-art-b1cce69693d14ac887bfdd32d77ea121 |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-b1cce69693d14ac887bfdd32d77ea1212025-08-23T04:47:57ZengElsevierStem Cell Research1873-50612025-09-018710380710.1016/j.scr.2025.103807Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutationDidi Shan0Hongxu Wang1Jianing Li2Yu Wang3Fuchen Liu4Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan 250012 Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan 250012 Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan 250012 Shandong, ChinaPrenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan 250012 Shandong, China; Corresponding author.We used a non-integrated reprogramming approach to establish a human induced pluripotent stem cell (hiPSC) line (INNDSUi011-A) from the skin fibroblasts of a 38-year-old female individual with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation. The cells obtained demonstrate key characteristics of embryonic stem cells, including the expression of specific pluripotency markers and the capacity to differentiate into the three germ layers in vitro. This iPSC cell line retains the patient’s genetic information, making it a valuable model for studying disease mechanisms and developing novel therapies.http://www.sciencedirect.com/science/article/pii/S1873506125001576 |
| spellingShingle | Didi Shan Hongxu Wang Jianing Li Yu Wang Fuchen Liu Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation Stem Cell Research |
| title | Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation |
| title_full | Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation |
| title_fullStr | Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation |
| title_full_unstemmed | Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation |
| title_short | Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation |
| title_sort | establishment of an induced pluripotent stem cell ipsc line inndsui011 a from a patient with autosomal dominant spastic paraplegia 9a due to aldh18a1 mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506125001576 |
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