Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis
Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | JID Innovations |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026725000463 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849319177548988416 |
|---|---|
| author | Katie Ridge Barry Moran Mark A. Little Cliona O’Farrelly Jean Dunne Julianne Clowry Clodagh Loftus Conor M. Finlay Alan D. Irvine Niall Conlon |
| author_facet | Katie Ridge Barry Moran Mark A. Little Cliona O’Farrelly Jean Dunne Julianne Clowry Clodagh Loftus Conor M. Finlay Alan D. Irvine Niall Conlon |
| author_sort | Katie Ridge |
| collection | DOAJ |
| description | Chronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2 polarization. Despite this, the role of mast cells in AD is important, given their release of proinflammatory mediators. Recently, myeloid and mast cell progenitors were identified as potential biomarkers for treatment response in chronic spontaneous urticaria. These Lin−CD117+CD34+FceRI+ cells appear to have increased egress from the bone marrow in atopy. We measured Lin−CD117+CD34+FceRI+ cells in the peripheral blood of 10 individuals with AD and 10 healthy controls. Flow cytometry revealed a significant increase in myeloid progenitors in participants with AD (P = .0067). Total serum IgE levels did not correlate with myeloid progenitors. To our knowledge, examination of this cell type in AD is previously unreported. Our findings suggest increased progenitor egress from the bone marrow in these patients and a possible role for myeloid progenitors in disease pathogenesis. |
| format | Article |
| id | doaj-art-b1c51bca2ff746e8b9ddb2c6342dc0fc |
| institution | Kabale University |
| issn | 2667-0267 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj-art-b1c51bca2ff746e8b9ddb2c6342dc0fc2025-08-20T03:50:32ZengElsevierJID Innovations2667-02672025-09-015510039010.1016/j.xjidi.2025.100390Myeloid and Mast Cell Progenitors Are Elevated in Atopic DermatitisKatie Ridge0Barry Moran1Mark A. Little2Cliona O’Farrelly3Jean Dunne4Julianne Clowry5Clodagh Loftus6Conor M. Finlay7Alan D. Irvine8Niall Conlon9UCARE Centre, Clinical and Diagnostic Immunology, St. James’s Hospital, Dublin, Ireland; Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Correspondence: Katie Ridge, UCARE Centre, Clinical and Diagnostic Immunology, St. James’s Hospital, James’s Street, Dublin D08 RX0X, Ireland.Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, IrelandClinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin, IrelandClinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, IrelandUCARE Centre, Clinical and Diagnostic Immunology, St. James’s Hospital, Dublin, IrelandClinical Medicine, School of Medicine, Trinity College Dublin, Dublin, IrelandDermatology, St. James’s Hospital, Dublin, IrelandClinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity Kidney Centre, Trinity Translational Medicine Institute, School of Medicine, Trinity College Dublin, Dublin, IrelandClinical Medicine, School of Medicine, Trinity College Dublin, Dublin, IrelandUCARE Centre, Clinical and Diagnostic Immunology, St. James’s Hospital, Dublin, Ireland; Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, IrelandChronic spontaneous urticaria and atopic dermatitis (AD) are chronic skin disorders characterized by itch. Although mast cells play an integral role in the pathogenesis of chronic spontaneous urticaria, their role in AD is unclear, having a contributory role in a disease largely driven by T helper 2 polarization. Despite this, the role of mast cells in AD is important, given their release of proinflammatory mediators. Recently, myeloid and mast cell progenitors were identified as potential biomarkers for treatment response in chronic spontaneous urticaria. These Lin−CD117+CD34+FceRI+ cells appear to have increased egress from the bone marrow in atopy. We measured Lin−CD117+CD34+FceRI+ cells in the peripheral blood of 10 individuals with AD and 10 healthy controls. Flow cytometry revealed a significant increase in myeloid progenitors in participants with AD (P = .0067). Total serum IgE levels did not correlate with myeloid progenitors. To our knowledge, examination of this cell type in AD is previously unreported. Our findings suggest increased progenitor egress from the bone marrow in these patients and a possible role for myeloid progenitors in disease pathogenesis.http://www.sciencedirect.com/science/article/pii/S2667026725000463Atopic dermatitisImmunologyMast cellsMyeloid cellsTranslational medicine |
| spellingShingle | Katie Ridge Barry Moran Mark A. Little Cliona O’Farrelly Jean Dunne Julianne Clowry Clodagh Loftus Conor M. Finlay Alan D. Irvine Niall Conlon Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis JID Innovations Atopic dermatitis Immunology Mast cells Myeloid cells Translational medicine |
| title | Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis |
| title_full | Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis |
| title_fullStr | Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis |
| title_full_unstemmed | Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis |
| title_short | Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis |
| title_sort | myeloid and mast cell progenitors are elevated in atopic dermatitis |
| topic | Atopic dermatitis Immunology Mast cells Myeloid cells Translational medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2667026725000463 |
| work_keys_str_mv | AT katieridge myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT barrymoran myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT markalittle myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT clionaofarrelly myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT jeandunne myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT julianneclowry myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT clodaghloftus myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT conormfinlay myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT alandirvine myeloidandmastcellprogenitorsareelevatedinatopicdermatitis AT niallconlon myeloidandmastcellprogenitorsareelevatedinatopicdermatitis |