Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study
Introduction: Sepsis is a leading cause of morbidity and mortality worldwide, and the Sequential Organ Failure Assessment (SOFA) score is used as a key criterion in diagnosing the sepsis syndrome. Recent studies have also suggested that vitamin D is an important mediator in the immune system and pla...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2024-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/20315/67325_CE[Ra1]_F(IS)_QC[PS_IS]_PF1(AG_SHU)_PFA(KM)_PFA_PB(AG_IS)_PN(IS).pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850058825937190912 |
|---|---|
| author | Sunita Lamichaney Priyam Goswami Monigopa Das Pranjal Kumar Dutta Tanvee Yusuf |
| author_facet | Sunita Lamichaney Priyam Goswami Monigopa Das Pranjal Kumar Dutta Tanvee Yusuf |
| author_sort | Sunita Lamichaney |
| collection | DOAJ |
| description | Introduction: Sepsis is a leading cause of morbidity and mortality worldwide, and the Sequential Organ Failure Assessment (SOFA) score is used as a key criterion in diagnosing the sepsis syndrome. Recent studies have also suggested that vitamin D is an important mediator in the immune system and plays an inhibitory role in sepsis.
Aim: To assess serum vitamin D levels in patients with sepsis and to investigate the correlation between vitamin D levels and the SOFA score, as well as the outcomes of sepsis.
Materials and Methods: This was a hospital-based cross-sectional study carried out on 91 patients diagnosed with sepsis. The SOFA score was calculated within 24 hours of admission and again at 72 hours; however, only the SOFA score obtained on admission (within 24 hours) was used to assess disease severity and to compare with vitamin D levels. Vitamin D assessment was conducted using a competitive immunoassay in the VITROS 5600 fully automated integrated assay system. Pearson’s correlation (r) was used to measure the association between variables.
Results: The mean age of the study population was 57.34±16.55 years, with a male to female ratio of 1.17:1. A significant increase in vitamin D deficiency was noted in patients with a SOFA score above 10. There was a negative correlation between serum vitamin D levels and the SOFA score within 24 hours after admission, which was statistically significant (p-value <0.001, r-value -0.420). In the vitamin D deficient group, 65.7% of patients died, demonstrating a significant negative association between vitamin D levels and mortality (p-value <0.001).
Conclusion: This study has shown that lower levels of vitamin D are associated with greater severity of sepsis upon admission. Additionally, lower vitamin D levels are linked to a higher mortality rate and poor outcomes. However, larger-scale, intervention-based trials of supplementary vitamin D therapy in the management of sepsis are required to strengthen the evidence of the correlation between these two variables. |
| format | Article |
| id | doaj-art-b1c4b5c4cf8c4e5498be16b8d4620a1b |
| institution | DOAJ |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-b1c4b5c4cf8c4e5498be16b8d4620a1b2025-08-20T02:51:02ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-11-011811212410.7860/JCDR/2024/67325.20315Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional StudySunita Lamichaney0Priyam Goswami1Monigopa Das2Pranjal Kumar Dutta3Tanvee Yusuf4Senior Resident, Department of Internal Medicine, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.Associate Professor, Department of Internal Medicine, Tinsukia Medical College and Hospital, Tinsukia, Assam, India.Professor, Department of Biochemistry, Assam Medical College and Hospital, Dibrugarh, Assam, India. Associate Professor, Department of Internal Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, India.Senior Resident, Department of Internal Medicine, Assam Medical College and Hospital, Dibrugarh, Assam, India.Introduction: Sepsis is a leading cause of morbidity and mortality worldwide, and the Sequential Organ Failure Assessment (SOFA) score is used as a key criterion in diagnosing the sepsis syndrome. Recent studies have also suggested that vitamin D is an important mediator in the immune system and plays an inhibitory role in sepsis. Aim: To assess serum vitamin D levels in patients with sepsis and to investigate the correlation between vitamin D levels and the SOFA score, as well as the outcomes of sepsis. Materials and Methods: This was a hospital-based cross-sectional study carried out on 91 patients diagnosed with sepsis. The SOFA score was calculated within 24 hours of admission and again at 72 hours; however, only the SOFA score obtained on admission (within 24 hours) was used to assess disease severity and to compare with vitamin D levels. Vitamin D assessment was conducted using a competitive immunoassay in the VITROS 5600 fully automated integrated assay system. Pearson’s correlation (r) was used to measure the association between variables. Results: The mean age of the study population was 57.34±16.55 years, with a male to female ratio of 1.17:1. A significant increase in vitamin D deficiency was noted in patients with a SOFA score above 10. There was a negative correlation between serum vitamin D levels and the SOFA score within 24 hours after admission, which was statistically significant (p-value <0.001, r-value -0.420). In the vitamin D deficient group, 65.7% of patients died, demonstrating a significant negative association between vitamin D levels and mortality (p-value <0.001). Conclusion: This study has shown that lower levels of vitamin D are associated with greater severity of sepsis upon admission. Additionally, lower vitamin D levels are linked to a higher mortality rate and poor outcomes. However, larger-scale, intervention-based trials of supplementary vitamin D therapy in the management of sepsis are required to strengthen the evidence of the correlation between these two variables.https://www.jcdr.net/articles/PDF/20315/67325_CE[Ra1]_F(IS)_QC[PS_IS]_PF1(AG_SHU)_PFA(KM)_PFA_PB(AG_IS)_PN(IS).pdfcholecalciferolsequential organ failure assessment scoresepticaemia |
| spellingShingle | Sunita Lamichaney Priyam Goswami Monigopa Das Pranjal Kumar Dutta Tanvee Yusuf Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study Journal of Clinical and Diagnostic Research cholecalciferol sequential organ failure assessment score septicaemia |
| title | Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study |
| title_full | Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study |
| title_fullStr | Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study |
| title_full_unstemmed | Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study |
| title_short | Serum Vitamin D Level in Patients with Sepsis and its Correlation with Sequential Organ Failure Assessment Score: A Cross-sectional Study |
| title_sort | serum vitamin d level in patients with sepsis and its correlation with sequential organ failure assessment score a cross sectional study |
| topic | cholecalciferol sequential organ failure assessment score septicaemia |
| url | https://www.jcdr.net/articles/PDF/20315/67325_CE[Ra1]_F(IS)_QC[PS_IS]_PF1(AG_SHU)_PFA(KM)_PFA_PB(AG_IS)_PN(IS).pdf |
| work_keys_str_mv | AT sunitalamichaney serumvitamindlevelinpatientswithsepsisanditscorrelationwithsequentialorganfailureassessmentscoreacrosssectionalstudy AT priyamgoswami serumvitamindlevelinpatientswithsepsisanditscorrelationwithsequentialorganfailureassessmentscoreacrosssectionalstudy AT monigopadas serumvitamindlevelinpatientswithsepsisanditscorrelationwithsequentialorganfailureassessmentscoreacrosssectionalstudy AT pranjalkumardutta serumvitamindlevelinpatientswithsepsisanditscorrelationwithsequentialorganfailureassessmentscoreacrosssectionalstudy AT tanveeyusuf serumvitamindlevelinpatientswithsepsisanditscorrelationwithsequentialorganfailureassessmentscoreacrosssectionalstudy |