The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice
Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to est...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2013/356107 |
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| author | J. N. Boampong E. O. Ameyaw B. Aboagye K. Asare S. Kyei J. H. Donfack E. Woode |
| author_facet | J. N. Boampong E. O. Ameyaw B. Aboagye K. Asare S. Kyei J. H. Donfack E. Woode |
| author_sort | J. N. Boampong |
| collection | DOAJ |
| description | Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected with Plasmodium berghei. Xylopic acid exerted significant (P<0.05) effects on P. berghei infection similar to artemether/lumefantrine, the standard drug. Furthermore, it significantly (P<0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone. Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent. |
| format | Article |
| id | doaj-art-b1c23de87bc6437e99d0727ecf692425 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-b1c23de87bc6437e99d0727ecf6924252025-02-03T05:45:10ZengWileyJournal of Parasitology Research2090-00232090-00312013-01-01201310.1155/2013/356107356107The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in MiceJ. N. Boampong0E. O. Ameyaw1B. Aboagye2K. Asare3S. Kyei4J. H. Donfack5E. Woode6Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Physical Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical Sciences, Faculty of Sciences, University of Dschang, P.O. Box 067, Dschang, CameroonDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, GhanaEfforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The antimalarial properties were determined by employing xylopic acid (10–100 mg/kg) in ICR mice infected with Plasmodium berghei. Xylopic acid exerted significant (P<0.05) effects on P. berghei infection similar to artemether/lumefantrine, the standard drug. Furthermore, it significantly (P<0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone. Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.http://dx.doi.org/10.1155/2013/356107 |
| spellingShingle | J. N. Boampong E. O. Ameyaw B. Aboagye K. Asare S. Kyei J. H. Donfack E. Woode The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice Journal of Parasitology Research |
| title | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice |
| title_full | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice |
| title_fullStr | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice |
| title_full_unstemmed | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice |
| title_short | The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice |
| title_sort | curative and prophylactic effects of xylopic acid on plasmodium berghei infection in mice |
| url | http://dx.doi.org/10.1155/2013/356107 |
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