A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth
Birth defects (BD) are an important cause of neonatal mortality and can be associated with premature birth. The study aimed to develop a prognostic model for congenital malformations in mothers with a history of preterm delivery, using logistic regression analysis. The study included 665 mothers of...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dnipro State Medical University
2024-04-01
|
| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | https://journals.uran.ua/index.php/2307-0404/article/view/300506 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841563869849321472 |
|---|---|
| author | G. Mammadzada |
| author_facet | G. Mammadzada |
| author_sort | G. Mammadzada |
| collection | DOAJ |
| description | Birth defects (BD) are an important cause of neonatal mortality and can be associated with premature birth. The study aimed to develop a prognostic model for congenital malformations in mothers with a history of preterm delivery, using logistic regression analysis. The study included 665 mothers of children with BD, of which 432 (65%) had a history of preterm delivery (main group), and 233 (35%) had term delivery (control group). Variables examined included pregnancy history, genetic factors, and biochemical markers. Statistical analysis found significant associations between BD and preterm delivery, intrauterine malformations, miscarriages, MTHFR polymorphism, and HLA antigens. The logistic model showed good predictive performance. The area under the ROC curve was 0.769 for pregnancy history, 0.699 for miscarriages, and 0.630 for intrauterine malformations, indicating moderate predictive ability. A statistical relationship was found between BD risk and pregnancy history, intrauterine malformations, miscarriages, and genetic factors. The resulting logistic model may help predict BD risk in mothers with a preterm delivery history. |
| format | Article |
| id | doaj-art-b1c0f87a4f75413c97e031d5efa32596 |
| institution | Kabale University |
| issn | 2307-0404 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-b1c0f87a4f75413c97e031d5efa325962025-01-02T23:29:52ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042024-04-012919010010.26641/2307-0404.2024.1.300506338870A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birthG. Mammadzada0https://orcid.org/0000-0001-5153-7068Scientific Research Institute of Obstetrics and Gynecology, Department of Neonatology, Kazim Kazimzade Str., 118, Baku, AZ1065Birth defects (BD) are an important cause of neonatal mortality and can be associated with premature birth. The study aimed to develop a prognostic model for congenital malformations in mothers with a history of preterm delivery, using logistic regression analysis. The study included 665 mothers of children with BD, of which 432 (65%) had a history of preterm delivery (main group), and 233 (35%) had term delivery (control group). Variables examined included pregnancy history, genetic factors, and biochemical markers. Statistical analysis found significant associations between BD and preterm delivery, intrauterine malformations, miscarriages, MTHFR polymorphism, and HLA antigens. The logistic model showed good predictive performance. The area under the ROC curve was 0.769 for pregnancy history, 0.699 for miscarriages, and 0.630 for intrauterine malformations, indicating moderate predictive ability. A statistical relationship was found between BD risk and pregnancy history, intrauterine malformations, miscarriages, and genetic factors. The resulting logistic model may help predict BD risk in mothers with a preterm delivery history.https://journals.uran.ua/index.php/2307-0404/article/view/300506regression analysisfetal anomaliesstatistical analysislogistic modelneonatal mortality |
| spellingShingle | G. Mammadzada A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth Medičnì Perspektivi regression analysis fetal anomalies statistical analysis logistic model neonatal mortality |
| title | A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| title_full | A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| title_fullStr | A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| title_full_unstemmed | A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| title_short | A model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| title_sort | model for predicting birth defects of the fetus based on risk factors in mothers with a history of premature birth |
| topic | regression analysis fetal anomalies statistical analysis logistic model neonatal mortality |
| url | https://journals.uran.ua/index.php/2307-0404/article/view/300506 |
| work_keys_str_mv | AT gmammadzada amodelforpredictingbirthdefectsofthefetusbasedonriskfactorsinmotherswithahistoryofprematurebirth AT gmammadzada modelforpredictingbirthdefectsofthefetusbasedonriskfactorsinmotherswithahistoryofprematurebirth |