Tempo and Mode of Transposable Element Activity in Drosophila.
The evolutionary dynamics of transposable element (TE) insertions have been of continued interest since TE activity has important implications for genome evolution and adaptation. Here, we infer the transposition dynamics of TEs by comparing their abundance in natural D. melanogaster and D. simulans...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-07-01
|
| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005406&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726631226114048 |
|---|---|
| author | Robert Kofler Viola Nolte Christian Schlötterer |
| author_facet | Robert Kofler Viola Nolte Christian Schlötterer |
| author_sort | Robert Kofler |
| collection | DOAJ |
| description | The evolutionary dynamics of transposable element (TE) insertions have been of continued interest since TE activity has important implications for genome evolution and adaptation. Here, we infer the transposition dynamics of TEs by comparing their abundance in natural D. melanogaster and D. simulans populations. Sequencing pools of more than 550 South African flies to at least 320-fold coverage, we determined the genome wide TE insertion frequencies in both species. We suggest that the predominance of low frequency insertions in the two species (>80% of the insertions have a frequency <0.2) is probably due to a high activity of more than 58 families in both species. We provide evidence for 50% of the TE families having temporally heterogenous transposition rates with different TE families being affected in the two species. While in D. melanogaster retrotransposons were more active, DNA transposons showed higher activity levels in D. simulans. Moreover, we suggest that LTR insertions are mostly of recent origin in both species, while DNA and non-LTR insertions are older and more frequently vertically transmitted since the split of D. melanogaster and D. simulans. We propose that the high TE activity is of recent origin in both species and a consequence of the demographic history, with habitat expansion triggering a period of rapid evolution. |
| format | Article |
| id | doaj-art-b1bbf66776c243c8a68b9ae149ae9721 |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-b1bbf66776c243c8a68b9ae149ae97212025-08-20T03:10:07ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042015-07-01117e100540610.1371/journal.pgen.1005406Tempo and Mode of Transposable Element Activity in Drosophila.Robert KoflerViola NolteChristian SchlöttererThe evolutionary dynamics of transposable element (TE) insertions have been of continued interest since TE activity has important implications for genome evolution and adaptation. Here, we infer the transposition dynamics of TEs by comparing their abundance in natural D. melanogaster and D. simulans populations. Sequencing pools of more than 550 South African flies to at least 320-fold coverage, we determined the genome wide TE insertion frequencies in both species. We suggest that the predominance of low frequency insertions in the two species (>80% of the insertions have a frequency <0.2) is probably due to a high activity of more than 58 families in both species. We provide evidence for 50% of the TE families having temporally heterogenous transposition rates with different TE families being affected in the two species. While in D. melanogaster retrotransposons were more active, DNA transposons showed higher activity levels in D. simulans. Moreover, we suggest that LTR insertions are mostly of recent origin in both species, while DNA and non-LTR insertions are older and more frequently vertically transmitted since the split of D. melanogaster and D. simulans. We propose that the high TE activity is of recent origin in both species and a consequence of the demographic history, with habitat expansion triggering a period of rapid evolution.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005406&type=printable |
| spellingShingle | Robert Kofler Viola Nolte Christian Schlötterer Tempo and Mode of Transposable Element Activity in Drosophila. PLoS Genetics |
| title | Tempo and Mode of Transposable Element Activity in Drosophila. |
| title_full | Tempo and Mode of Transposable Element Activity in Drosophila. |
| title_fullStr | Tempo and Mode of Transposable Element Activity in Drosophila. |
| title_full_unstemmed | Tempo and Mode of Transposable Element Activity in Drosophila. |
| title_short | Tempo and Mode of Transposable Element Activity in Drosophila. |
| title_sort | tempo and mode of transposable element activity in drosophila |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005406&type=printable |
| work_keys_str_mv | AT robertkofler tempoandmodeoftransposableelementactivityindrosophila AT violanolte tempoandmodeoftransposableelementactivityindrosophila AT christianschlotterer tempoandmodeoftransposableelementactivityindrosophila |