Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study.
<h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided mate...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0079803 |
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| author | Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy |
| author_facet | Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy |
| author_sort | Kelly Morgan |
| collection | DOAJ |
| description | <h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status.<h4>Findings</h4>We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)).<h4>Conclusion</h4>The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'. |
| format | Article |
| id | doaj-art-b1b93d1cb3d947ebbb629518b6cb6507 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-b1b93d1cb3d947ebbb629518b6cb65072025-08-20T03:10:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7980310.1371/journal.pone.0079803Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study.Kelly MorganMohammed RahmanMark AtkinsonShang-Ming ZhouRebecca HillAshrafunnesa KhanomShantini ParanjothySinead Brophy<h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status.<h4>Findings</h4>We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)).<h4>Conclusion</h4>The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.https://doi.org/10.1371/journal.pone.0079803 |
| spellingShingle | Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. PLoS ONE |
| title | Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_full | Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_fullStr | Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_full_unstemmed | Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_short | Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_sort | association of diabetes in pregnancy with child weight at birth age 12 months and 5 years a population based electronic cohort study |
| url | https://doi.org/10.1371/journal.pone.0079803 |
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