Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review
Abstract Background S. haematobium is a recognized carcinogen and is associated with squamous cell carcinoma of the bladder. Its association with high-risk(HR) human papillomavirus (HPV) persistence, cervical pre-cancer and cervical cancer incidence has not been fully explored. Methods We searched O...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12905-024-03514-0 |
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| author | Amy Sturt Tanvier Omar Isaiah Hansingo Paul Kamfwa Amaya Bustinduy Helen Kelly |
| author_facet | Amy Sturt Tanvier Omar Isaiah Hansingo Paul Kamfwa Amaya Bustinduy Helen Kelly |
| author_sort | Amy Sturt |
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| description | Abstract Background S. haematobium is a recognized carcinogen and is associated with squamous cell carcinoma of the bladder. Its association with high-risk(HR) human papillomavirus (HPV) persistence, cervical pre-cancer and cervical cancer incidence has not been fully explored. Methods We searched OvidSP MEDLINE, OvidSP Embase, Global Index Medicus, PubMed and the Wiley Cochrane library without date or language restrictions up to April 20, 2024 for abstracts evaluating the association of female genital schistosomiasis (FGS) with the prevalence, incidence or persistence of cervical HR-HPV, and incidence of histology-verified cervical pre-cancer or cancer. Cervical pre-cancer defined using cervical cytology or visual inspection with acetic acid (VIA) was also considered, but as lower quality evidence. We assessed the risk of bias of included studies using a modified Newcastle Ottawa scale. This study is registered on PROSPERO: CRD42023389301. Results We identified 1,170 publications and six studies were eligible for inclusion. Five studies were cross sectional and 1 was prospective. The studies describe 1081 women living in sub-Saharan Africa. One study from Zimbabwe reported an increased risk of HR-HPV prevalence at baseline in women with composite-FGS compared to women without FGS (aOR 1.9, 95% CI 1.1 – 3.6, p = 0.03), however no association was seen after 5 years of follow-up. Another study from KwaZulu-Natal reported an increased odds of any HPV prevalence among women with visual-FGS compared to women without FGS (aOR 1.71 [1.14 – 2.56], p = 0.01). However, a study in Madagascar did not show increased odds of any HPV among women with visual-FGS compared to women without FGS (OR 1.0 [0.82 – 1.2). Of 4 studies evaluating the association of FGS and cervical pre-cancer, one reported an increased risk of VIA abnormalities in women with molecular-FGS compared to those without (aOR 6.08, 95% CI 1.58 – 23.37). Three studies did not report an association between FGS and cervical pre-cancer (cytology defined (n = 2) and histology defined (n = 1)). Conclusion There are limited and low quality data on the risk of HR-HPV infection and cervical pre-cancer and cancer among women with FGS. Given limited data, it was not possible to confirm or exclude an association between FGS and HPV, cervical pre-cancer, and cervical cancer and additional research is needed. |
| format | Article |
| id | doaj-art-b1b871d3e01344cda826c91b99953a03 |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Women's Health |
| spelling | doaj-art-b1b871d3e01344cda826c91b99953a032025-01-05T12:44:43ZengBMCBMC Women's Health1472-68742025-01-0125111310.1186/s12905-024-03514-0Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic reviewAmy Sturt0Tanvier Omar1Isaiah Hansingo2Paul Kamfwa3Amaya Bustinduy4Helen Kelly5Infectious Diseases Section, Veterans Affairs Health Care SystemFaculty of Health Sciences, University of WitwatersrandDepartment of Obstetrics and Gynaecology, Livingstone Central HospitalDepartment of Gynecology Oncology, Cancer Diseases HospitalDepartment of Clinical Research, London School of Hygiene and Tropical MedicineDepartment of Clinical Research, London School of Hygiene and Tropical MedicineAbstract Background S. haematobium is a recognized carcinogen and is associated with squamous cell carcinoma of the bladder. Its association with high-risk(HR) human papillomavirus (HPV) persistence, cervical pre-cancer and cervical cancer incidence has not been fully explored. Methods We searched OvidSP MEDLINE, OvidSP Embase, Global Index Medicus, PubMed and the Wiley Cochrane library without date or language restrictions up to April 20, 2024 for abstracts evaluating the association of female genital schistosomiasis (FGS) with the prevalence, incidence or persistence of cervical HR-HPV, and incidence of histology-verified cervical pre-cancer or cancer. Cervical pre-cancer defined using cervical cytology or visual inspection with acetic acid (VIA) was also considered, but as lower quality evidence. We assessed the risk of bias of included studies using a modified Newcastle Ottawa scale. This study is registered on PROSPERO: CRD42023389301. Results We identified 1,170 publications and six studies were eligible for inclusion. Five studies were cross sectional and 1 was prospective. The studies describe 1081 women living in sub-Saharan Africa. One study from Zimbabwe reported an increased risk of HR-HPV prevalence at baseline in women with composite-FGS compared to women without FGS (aOR 1.9, 95% CI 1.1 – 3.6, p = 0.03), however no association was seen after 5 years of follow-up. Another study from KwaZulu-Natal reported an increased odds of any HPV prevalence among women with visual-FGS compared to women without FGS (aOR 1.71 [1.14 – 2.56], p = 0.01). However, a study in Madagascar did not show increased odds of any HPV among women with visual-FGS compared to women without FGS (OR 1.0 [0.82 – 1.2). Of 4 studies evaluating the association of FGS and cervical pre-cancer, one reported an increased risk of VIA abnormalities in women with molecular-FGS compared to those without (aOR 6.08, 95% CI 1.58 – 23.37). Three studies did not report an association between FGS and cervical pre-cancer (cytology defined (n = 2) and histology defined (n = 1)). Conclusion There are limited and low quality data on the risk of HR-HPV infection and cervical pre-cancer and cancer among women with FGS. Given limited data, it was not possible to confirm or exclude an association between FGS and HPV, cervical pre-cancer, and cervical cancer and additional research is needed.https://doi.org/10.1186/s12905-024-03514-0Female genital schistosomiaisis (FGS)Schistosoma haematobiumHuman papillomavirus (HPV)Pre-cancerCervical cancer |
| spellingShingle | Amy Sturt Tanvier Omar Isaiah Hansingo Paul Kamfwa Amaya Bustinduy Helen Kelly Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review BMC Women's Health Female genital schistosomiaisis (FGS) Schistosoma haematobium Human papillomavirus (HPV) Pre-cancer Cervical cancer |
| title | Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review |
| title_full | Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review |
| title_fullStr | Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review |
| title_full_unstemmed | Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review |
| title_short | Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review |
| title_sort | association of female genital schistosomiasis and human papillomavirus and cervical pre cancer a systematic review |
| topic | Female genital schistosomiaisis (FGS) Schistosoma haematobium Human papillomavirus (HPV) Pre-cancer Cervical cancer |
| url | https://doi.org/10.1186/s12905-024-03514-0 |
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