Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study
Purpose: We aimed to investigate the risk of developing depression in individuals with primary open-angle glaucoma with associated vision impairment. Methods: We conducted a nationwide, population-based cohort study using data from the Korean National Health Information Database and National Disabil...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024166480 |
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| author | Sheng-Min Wang Younhea Jung Kyungdo Han Kyoung Ohn Hae-young Lopilly Park Chan Kee Park Jung Il Moon |
| author_facet | Sheng-Min Wang Younhea Jung Kyungdo Han Kyoung Ohn Hae-young Lopilly Park Chan Kee Park Jung Il Moon |
| author_sort | Sheng-Min Wang |
| collection | DOAJ |
| description | Purpose: We aimed to investigate the risk of developing depression in individuals with primary open-angle glaucoma with associated vision impairment. Methods: We conducted a nationwide, population-based cohort study using data from the Korean National Health Information Database and National Disability Registry. We assessed baseline characteristics such as age, sex, income level, lifestyle factors, anthropometric data, lab results, and Charlson Comorbidity Index scores through diagnostic codes and health screening data. Depression risk in relation to glaucoma and vision impairment was analyzed using a multivariable-adjusted Cox proportional hazard model. Results: Among 3,680,570 individuals screened through the Korean National Health Screening Program in 2009, 681,515 were newly diagnosed with depression during follow-up. Subjects with glaucoma showed a higher risk of depression than those without glaucoma, with an adjusted hazard ratio (HR) of 2.011 (95 % confidence interval [CI]: 1.946–2.078) pre-adjustment and 1.085 (95 % CI: 1.050–1.121) post-adjustment for covariates. For those with glaucoma and vision impairment, the adjusted HR increased to 1.164 (95 % CI: 1.045–1.297) and to 1.207 (95 % CI: 1.039–1.403) with severe vision impairment. The association between glaucoma and depression was more pronounced in men (P for interaction = 0.001) and those with a Charlson Comorbidity Index <3 (P for interaction = 0.008). Conclusions: Primary open-angle glaucoma increased the risk of developing depression. The risk escalated gradually with the presence and severity of concurrent vision impairment. The impact of glaucoma and vision impairment on new-onset depression was greater in men and in those with less comorbidities. |
| format | Article |
| id | doaj-art-b1b8598aaad948a998d6868369477118 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b1b8598aaad948a998d68683694771182025-01-17T04:49:42ZengElsevierHeliyon2405-84402025-01-01111e40617Risk of depression in glaucoma patients with vision impairment: A nationwide cohort studySheng-Min Wang0Younhea Jung1Kyungdo Han2Kyoung Ohn3Hae-young Lopilly Park4Chan Kee Park5Jung Il Moon6Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Corresponding author. Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 07345, Republic of Korea.Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of KoreaDepartment of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaPurpose: We aimed to investigate the risk of developing depression in individuals with primary open-angle glaucoma with associated vision impairment. Methods: We conducted a nationwide, population-based cohort study using data from the Korean National Health Information Database and National Disability Registry. We assessed baseline characteristics such as age, sex, income level, lifestyle factors, anthropometric data, lab results, and Charlson Comorbidity Index scores through diagnostic codes and health screening data. Depression risk in relation to glaucoma and vision impairment was analyzed using a multivariable-adjusted Cox proportional hazard model. Results: Among 3,680,570 individuals screened through the Korean National Health Screening Program in 2009, 681,515 were newly diagnosed with depression during follow-up. Subjects with glaucoma showed a higher risk of depression than those without glaucoma, with an adjusted hazard ratio (HR) of 2.011 (95 % confidence interval [CI]: 1.946–2.078) pre-adjustment and 1.085 (95 % CI: 1.050–1.121) post-adjustment for covariates. For those with glaucoma and vision impairment, the adjusted HR increased to 1.164 (95 % CI: 1.045–1.297) and to 1.207 (95 % CI: 1.039–1.403) with severe vision impairment. The association between glaucoma and depression was more pronounced in men (P for interaction = 0.001) and those with a Charlson Comorbidity Index <3 (P for interaction = 0.008). Conclusions: Primary open-angle glaucoma increased the risk of developing depression. The risk escalated gradually with the presence and severity of concurrent vision impairment. The impact of glaucoma and vision impairment on new-onset depression was greater in men and in those with less comorbidities.http://www.sciencedirect.com/science/article/pii/S2405844024166480DepressionPrimary open-angle glaucomaGlaucomaVision impairmentEpidemiology |
| spellingShingle | Sheng-Min Wang Younhea Jung Kyungdo Han Kyoung Ohn Hae-young Lopilly Park Chan Kee Park Jung Il Moon Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study Heliyon Depression Primary open-angle glaucoma Glaucoma Vision impairment Epidemiology |
| title | Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study |
| title_full | Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study |
| title_fullStr | Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study |
| title_full_unstemmed | Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study |
| title_short | Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study |
| title_sort | risk of depression in glaucoma patients with vision impairment a nationwide cohort study |
| topic | Depression Primary open-angle glaucoma Glaucoma Vision impairment Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024166480 |
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