Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population
PurposeStudies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis of causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in the Asian population.Patients and methodsGenome...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1466190/full |
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| author | Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Haotian Chen Haotian Chen Yongqiang Liu Yongqiang Liu Libin Zou Libin Zou Zhijin Zhang Zhijin Zhang Zhiqiang Yin Zhiqiang Yin Shiyu Mao Shiyu Mao Changcheng Guo Changcheng Guo Bin Yang Bin Yang Pengfei Wu Pengfei Wu Pengfei Wu Xudong Yao Xudong Yao |
| author_facet | Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Haotian Chen Haotian Chen Yongqiang Liu Yongqiang Liu Libin Zou Libin Zou Zhijin Zhang Zhijin Zhang Zhiqiang Yin Zhiqiang Yin Shiyu Mao Shiyu Mao Changcheng Guo Changcheng Guo Bin Yang Bin Yang Pengfei Wu Pengfei Wu Pengfei Wu Xudong Yao Xudong Yao |
| author_sort | Zhengshi Wang |
| collection | DOAJ |
| description | PurposeStudies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis of causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in the Asian population.Patients and methodsGenome-wide association study (GWAS) summary datasets were collected from the public databases. There were 418 bacterial traits, 452 metabolites, 91 cytokines, 5408 cases of prostate cancer from East Asia, and 109,347 controls included. Mendelian randomization (MR) analyses were performed to investigate their causal relationships. Sensitivity analyses were conducted to test the reliability of MR results. Furthermore, the FinnGen database was used to assess the generalizability of our findings based on Asians.ResultsThere were a total of 17 bacterial traits, 28 metabolites (including 2 microbiota-associated metabolites), and 9 cytokines to be significantly associated with prostate cancer in Asians (P < 0.05). Further MR analyses of these positive results indicated that G_Ruminococcaceae UCG014/TNFSF10 axis, G_Anaerofilum/TNFRSF14 axis, G_Erysipelotrichaceae UCG003/TNFSF10 axis, and P_Proteobacteria/cholesterol axis were key signaling pathways involved in the progression of prostate cancer. Notably, G_Ruminococcaceae UCG014/TNFSF10 axis and G_Anaerofilum/TNFRSF14 axis were found to act as protective factors, while the other two signaling axes played a crucial role in promoting the progression of prostate cancer. Sensitivity analyses further confirmed the reliability of our findings. Using the European population as outcome, we further assessed the generalizability of our conclusions and found limited applicability to Europeans.ConclusionsWe found that there were causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in Asians. The causal effects of gut microbiota on prostate cancer were partially mediated by metabolites and cytokines. These findings might contribute to the development of new therapeutic strategies for prostate cancer. |
| format | Article |
| id | doaj-art-b1ad887f866e4e5a964e1f41f0373a20 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-b1ad887f866e4e5a964e1f41f0373a202025-01-15T05:11:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14661901466190Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian populationZhengshi Wang0Zhengshi Wang1Zhengshi Wang2Zhengshi Wang3Zhengshi Wang4Haotian Chen5Haotian Chen6Yongqiang Liu7Yongqiang Liu8Libin Zou9Libin Zou10Zhijin Zhang11Zhijin Zhang12Zhiqiang Yin13Zhiqiang Yin14Shiyu Mao15Shiyu Mao16Changcheng Guo17Changcheng Guo18Bin Yang19Bin Yang20Pengfei Wu21Pengfei Wu22Pengfei Wu23Xudong Yao24Xudong Yao25Department of Urology, Shanghai Tenth People’s Hospital, Clinical Medical College of Nanjing Medical University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Breast and Thyroid Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaShanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Breast and Thyroid Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaShanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, Clinical Medical College of Nanjing Medical University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaUrologic Cancer Institute, School of Medicine, Tongji University, Shanghai, ChinaPurposeStudies have shown that gut microbiota is involved in the tumorigenesis and development of prostate cancer. We aimed to perform a comprehensive analysis of causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in the Asian population.Patients and methodsGenome-wide association study (GWAS) summary datasets were collected from the public databases. There were 418 bacterial traits, 452 metabolites, 91 cytokines, 5408 cases of prostate cancer from East Asia, and 109,347 controls included. Mendelian randomization (MR) analyses were performed to investigate their causal relationships. Sensitivity analyses were conducted to test the reliability of MR results. Furthermore, the FinnGen database was used to assess the generalizability of our findings based on Asians.ResultsThere were a total of 17 bacterial traits, 28 metabolites (including 2 microbiota-associated metabolites), and 9 cytokines to be significantly associated with prostate cancer in Asians (P < 0.05). Further MR analyses of these positive results indicated that G_Ruminococcaceae UCG014/TNFSF10 axis, G_Anaerofilum/TNFRSF14 axis, G_Erysipelotrichaceae UCG003/TNFSF10 axis, and P_Proteobacteria/cholesterol axis were key signaling pathways involved in the progression of prostate cancer. Notably, G_Ruminococcaceae UCG014/TNFSF10 axis and G_Anaerofilum/TNFRSF14 axis were found to act as protective factors, while the other two signaling axes played a crucial role in promoting the progression of prostate cancer. Sensitivity analyses further confirmed the reliability of our findings. Using the European population as outcome, we further assessed the generalizability of our conclusions and found limited applicability to Europeans.ConclusionsWe found that there were causal associations of gut microbiota, metabolites, and cytokines with prostate cancer in Asians. The causal effects of gut microbiota on prostate cancer were partially mediated by metabolites and cytokines. These findings might contribute to the development of new therapeutic strategies for prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2024.1466190/fullprostate cancerGWASgut microbiotasingle nucleotide polymorphismcytokine |
| spellingShingle | Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Zhengshi Wang Haotian Chen Haotian Chen Yongqiang Liu Yongqiang Liu Libin Zou Libin Zou Zhijin Zhang Zhijin Zhang Zhiqiang Yin Zhiqiang Yin Shiyu Mao Shiyu Mao Changcheng Guo Changcheng Guo Bin Yang Bin Yang Pengfei Wu Pengfei Wu Pengfei Wu Xudong Yao Xudong Yao Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population Frontiers in Oncology prostate cancer GWAS gut microbiota single nucleotide polymorphism cytokine |
| title | Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population |
| title_full | Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population |
| title_fullStr | Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population |
| title_full_unstemmed | Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population |
| title_short | Gut microbiota, metabolites, and cytokines in relation to the risk of prostate cancer in the Asian population |
| title_sort | gut microbiota metabolites and cytokines in relation to the risk of prostate cancer in the asian population |
| topic | prostate cancer GWAS gut microbiota single nucleotide polymorphism cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1466190/full |
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