Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital
Background: The illness known as acute-on-chronic liver failure (ACLF) was just recently identified and characterized which is linked to morbidity and deaths. Several prognostic models are available to stratify these patients. Objective: The objective was to compare the performance of different...
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| Format: | Article |
| Language: | English |
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Liaquat National Hospital and Medical College
2023-04-01
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| Series: | Journal of Liaquat National Hospital |
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| Online Access: | https://journals.lnh.edu.pk/jlnh/pdf/406d1863-362c-4373-93e9-ba68dba5980d.pdf |
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| author | Raja Taha Yaseen Khan Hina Ismail Abbas Ali Tasneem Saleem Shahzad Shoaib Ahmed Khan Mehboob Jan Syed Mudassir Laeeq Zain Majid Muhammad Qaiser Panezai Danish Kumar Nasir Hasan Luck |
| author_facet | Raja Taha Yaseen Khan Hina Ismail Abbas Ali Tasneem Saleem Shahzad Shoaib Ahmed Khan Mehboob Jan Syed Mudassir Laeeq Zain Majid Muhammad Qaiser Panezai Danish Kumar Nasir Hasan Luck |
| author_sort | Raja Taha Yaseen Khan |
| collection | DOAJ |
| description | Background:
The illness known as acute-on-chronic liver failure (ACLF) was just recently identified and characterized which is linked to morbidity and
deaths. Several prognostic models are available to stratify these patients.
Objective:
The objective was to compare the performance of different non-invasive available models in predicting one-month and six months mortality
in ACLF.
Methods:
This retrospective observational study included patients of age range 8-70 years of any gender having liver cirrhosis and fulfilling the
criteria of ACLF from January 2019 to December 2022. The predesigned formula was used to calculate scores based on different models.
The outcome was noted in terms of one month and six months of mortality in each patient. The receiver operative curve was constructed for
six prognostic models available for predicting 30-day and six months mortality in ACLF patients. These scores were subjected to
multivariable cox-regression analysis to determine the independent determinants of both short- and long-term mortality in ACLF patients.
Results:
A total of 235 patients were studied in this retrospective investigation. A one-month mortality rate of 78 patients (33.2%) and a six-month
mortality rate of 155 patients (66%) were recorded, respectively. CTP score, MELD score, LBi, CLIF-SOFA, and CLIF-ACLF were
independent predictors of one-month mortality on multivariate cox-regression analysis, but only CTP score, MELD score, and LBi were
independent predictors of mortality at six months.
Conclusion:
Among the six prognostic scores used for the ICU-admitted ACLF patients, LBi was the most efficient predictor of both one-month and six
months mortality while CLIF-C SOFA and CLIF ACLF were good predictors of both mortalities. CTP and MELD scores were useful in
forecasting six months' mortality. |
| format | Article |
| id | doaj-art-b1a9bc4309054cbba5ae4755e16e4db3 |
| institution | OA Journals |
| issn | 2959-1805 2960-2963 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Journal of Liaquat National Hospital |
| spelling | doaj-art-b1a9bc4309054cbba5ae4755e16e4db32025-08-20T02:10:35ZengLiaquat National Hospital and Medical CollegeJournal of Liaquat National Hospital2959-18052960-29632023-04-011131110.37184/jlnh.2959-1805.1.8Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care HospitalRaja Taha Yaseen Khan0Hina Ismail1Abbas Ali Tasneem2Saleem Shahzad3Shoaib Ahmed Khan4Mehboob Jan5Syed Mudassir Laeeq6Zain Majid7Muhammad Qaiser Panezai8Danish Kumar9Nasir Hasan Luck10Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanDepartment of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, PakistanBackground: The illness known as acute-on-chronic liver failure (ACLF) was just recently identified and characterized which is linked to morbidity and deaths. Several prognostic models are available to stratify these patients. Objective: The objective was to compare the performance of different non-invasive available models in predicting one-month and six months mortality in ACLF. Methods: This retrospective observational study included patients of age range 8-70 years of any gender having liver cirrhosis and fulfilling the criteria of ACLF from January 2019 to December 2022. The predesigned formula was used to calculate scores based on different models. The outcome was noted in terms of one month and six months of mortality in each patient. The receiver operative curve was constructed for six prognostic models available for predicting 30-day and six months mortality in ACLF patients. These scores were subjected to multivariable cox-regression analysis to determine the independent determinants of both short- and long-term mortality in ACLF patients. Results: A total of 235 patients were studied in this retrospective investigation. A one-month mortality rate of 78 patients (33.2%) and a six-month mortality rate of 155 patients (66%) were recorded, respectively. CTP score, MELD score, LBi, CLIF-SOFA, and CLIF-ACLF were independent predictors of one-month mortality on multivariate cox-regression analysis, but only CTP score, MELD score, and LBi were independent predictors of mortality at six months. Conclusion: Among the six prognostic scores used for the ICU-admitted ACLF patients, LBi was the most efficient predictor of both one-month and six months mortality while CLIF-C SOFA and CLIF ACLF were good predictors of both mortalities. CTP and MELD scores were useful in forecasting six months' mortality.https://journals.lnh.edu.pk/jlnh/pdf/406d1863-362c-4373-93e9-ba68dba5980d.pdfacute on chronic liver failureprognostic modelsmortality |
| spellingShingle | Raja Taha Yaseen Khan Hina Ismail Abbas Ali Tasneem Saleem Shahzad Shoaib Ahmed Khan Mehboob Jan Syed Mudassir Laeeq Zain Majid Muhammad Qaiser Panezai Danish Kumar Nasir Hasan Luck Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital Journal of Liaquat National Hospital acute on chronic liver failure prognostic models mortality |
| title | Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital |
| title_full | Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital |
| title_fullStr | Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital |
| title_full_unstemmed | Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital |
| title_short | Comparison of Different Scores in Predicting Mortality in Patients with Acute on Chronic Liver Failure Admitted to the Intensive Care Unit of a Tertiary Care Hospital |
| title_sort | comparison of different scores in predicting mortality in patients with acute on chronic liver failure admitted to the intensive care unit of a tertiary care hospital |
| topic | acute on chronic liver failure prognostic models mortality |
| url | https://journals.lnh.edu.pk/jlnh/pdf/406d1863-362c-4373-93e9-ba68dba5980d.pdf |
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