Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism
Congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism history usually have poor spermatogenesis outcome, while researches focusing on this population are rare. This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/6743489 |
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| author | Zhaoxiang Liu Jiangfeng Mao Hongli Xu Xi Wang Bingkun Huang Junjie Zheng Min Nie Hongbing Zhang Xueyan Wu |
| author_facet | Zhaoxiang Liu Jiangfeng Mao Hongli Xu Xi Wang Bingkun Huang Junjie Zheng Min Nie Hongbing Zhang Xueyan Wu |
| author_sort | Zhaoxiang Liu |
| collection | DOAJ |
| description | Congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism history usually have poor spermatogenesis outcome, while researches focusing on this population are rare. This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism (n = 40). One hundred and eighty-three CHH patients without cryptorchidism were served as control. All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months. The median follow-up period was 24 (15, 33) months (totally 960 person-months). Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8–30.2). Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to produce first sperm was 19 ± 8 months. Five pregnancies were achieved in 9 (5/9, 56%) couples who desired for children. Compared with CHH patients without cryptorchidism (n = 183), cryptorchid patients had longer median time for sperm appearance in semen (24 months vs. 15 months, P<0.001), lower rate of spermatogenesis (50% vs. 67%, P=0.032), and lower mean sperm concentration (1.9 (0.5, 8.6) million/ml vs. 11.1(1.0, 25.0) million/ml, P=0.006) at the last visit. In conclusion, CHH patients with cryptorchidism require a longer period for gonadotropin-induced spermatogenesis. The successful rate and sperm concentration were lower than patients without cryptorchidism. |
| format | Article |
| id | doaj-art-b1a773c1905c4254b623c97dce1bdb3d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b1a773c1905c4254b623c97dce1bdb3d2025-08-20T03:39:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/67434896743489Gonadotropin-Induced Spermatogenesis in CHH Patients with CryptorchidismZhaoxiang Liu0Jiangfeng Mao1Hongli Xu2Xi Wang3Bingkun Huang4Junjie Zheng5Min Nie6Hongbing Zhang7Xueyan Wu8Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaDepartment of Physiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, National Health Commission of People's Republic of China, Beijing, ChinaCongenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism history usually have poor spermatogenesis outcome, while researches focusing on this population are rare. This study retrospectively evaluated gonadotropin-induced spermatogenesis outcome in CHH patients with cryptorchidism (n = 40). One hundred and eighty-three CHH patients without cryptorchidism were served as control. All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months. The median follow-up period was 24 (15, 33) months (totally 960 person-months). Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8–30.2). Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to produce first sperm was 19 ± 8 months. Five pregnancies were achieved in 9 (5/9, 56%) couples who desired for children. Compared with CHH patients without cryptorchidism (n = 183), cryptorchid patients had longer median time for sperm appearance in semen (24 months vs. 15 months, P<0.001), lower rate of spermatogenesis (50% vs. 67%, P=0.032), and lower mean sperm concentration (1.9 (0.5, 8.6) million/ml vs. 11.1(1.0, 25.0) million/ml, P=0.006) at the last visit. In conclusion, CHH patients with cryptorchidism require a longer period for gonadotropin-induced spermatogenesis. The successful rate and sperm concentration were lower than patients without cryptorchidism.http://dx.doi.org/10.1155/2019/6743489 |
| spellingShingle | Zhaoxiang Liu Jiangfeng Mao Hongli Xu Xi Wang Bingkun Huang Junjie Zheng Min Nie Hongbing Zhang Xueyan Wu Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism International Journal of Endocrinology |
| title | Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism |
| title_full | Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism |
| title_fullStr | Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism |
| title_full_unstemmed | Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism |
| title_short | Gonadotropin-Induced Spermatogenesis in CHH Patients with Cryptorchidism |
| title_sort | gonadotropin induced spermatogenesis in chh patients with cryptorchidism |
| url | http://dx.doi.org/10.1155/2019/6743489 |
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