The Importance of Velocity Acceleration to Flow-Mediated Dilation
The validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention has been given to the most appropriate blood velocity parameter(s) for cal...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/589213 |
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| author | Lee Stoner Joanna M. Young Simon Fryer Manning J. Sabatier |
| author_facet | Lee Stoner Joanna M. Young Simon Fryer Manning J. Sabatier |
| author_sort | Lee Stoner |
| collection | DOAJ |
| description | The validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention has been given to the most appropriate blood velocity parameter(s) for calculating shear stress. The pulsatile nature of blood flow exposes the endothelial cells to two distinct shear stimuli during the cardiac cycle: a large rate of change in shear at the onset of flow (velocity acceleration), followed by a steady component. The parameter typically entered into the Poiseuille's law equation to determine shear stress is time-averaged blood velocity, with no regard for flow pulsatility. This paper will discuss (1) the limitations of using Posieuille's law to estimate shear stress and (2) the importance of the velocity profile—with emphasis on velocity acceleration—to endothelial function and vascular tone. |
| format | Article |
| id | doaj-art-b1a1eb9ca9e1461080baff2d3c852ffd |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-b1a1eb9ca9e1461080baff2d3c852ffd2025-08-20T03:39:26ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/589213589213The Importance of Velocity Acceleration to Flow-Mediated DilationLee Stoner0Joanna M. Young1Simon Fryer2Manning J. Sabatier3School of Sport and Exercise, Massey University, Wellington, New ZealandLipid and Diabetes Research Group, Diabetes Research Institute, Christchurch Hospital, Christchurch, New ZealandSchool of Sciences and Physical Education, University of Canterbury, Christchurch, New ZealandDivision of Biological Sciences, Clayton State University, Morrow, GA, USAThe validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention has been given to the most appropriate blood velocity parameter(s) for calculating shear stress. The pulsatile nature of blood flow exposes the endothelial cells to two distinct shear stimuli during the cardiac cycle: a large rate of change in shear at the onset of flow (velocity acceleration), followed by a steady component. The parameter typically entered into the Poiseuille's law equation to determine shear stress is time-averaged blood velocity, with no regard for flow pulsatility. This paper will discuss (1) the limitations of using Posieuille's law to estimate shear stress and (2) the importance of the velocity profile—with emphasis on velocity acceleration—to endothelial function and vascular tone.http://dx.doi.org/10.1155/2012/589213 |
| spellingShingle | Lee Stoner Joanna M. Young Simon Fryer Manning J. Sabatier The Importance of Velocity Acceleration to Flow-Mediated Dilation International Journal of Vascular Medicine |
| title | The Importance of Velocity Acceleration to Flow-Mediated Dilation |
| title_full | The Importance of Velocity Acceleration to Flow-Mediated Dilation |
| title_fullStr | The Importance of Velocity Acceleration to Flow-Mediated Dilation |
| title_full_unstemmed | The Importance of Velocity Acceleration to Flow-Mediated Dilation |
| title_short | The Importance of Velocity Acceleration to Flow-Mediated Dilation |
| title_sort | importance of velocity acceleration to flow mediated dilation |
| url | http://dx.doi.org/10.1155/2012/589213 |
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