Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach
Background: Articular damage is a marker of hereditary hemophilia, especially affecting the large joints of the upper and lower limbs. This retrospective study aimed to emphasize that hereditary coagulopathies, specifically hemophilia A and B, require a multidisciplinary approach due to their comple...
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MDPI AG
2025-03-01
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| author | Cristina Claudia Tarniceriu Loredana Liliana Hurjui Daniela Maria Tanase Anca Haisan Razvan Tudor Tepordei Gabriel Statescu Simona Alice Partene Vicoleanu Ancuta Lupu Vasile Valeriu Lupu Manuela Ursaru Alin Horatiu Nedelcu |
| author_facet | Cristina Claudia Tarniceriu Loredana Liliana Hurjui Daniela Maria Tanase Anca Haisan Razvan Tudor Tepordei Gabriel Statescu Simona Alice Partene Vicoleanu Ancuta Lupu Vasile Valeriu Lupu Manuela Ursaru Alin Horatiu Nedelcu |
| author_sort | Cristina Claudia Tarniceriu |
| collection | DOAJ |
| description | Background: Articular damage is a marker of hereditary hemophilia, especially affecting the large joints of the upper and lower limbs. This retrospective study aimed to emphasize that hereditary coagulopathies, specifically hemophilia A and B, require a multidisciplinary approach due to their complex nature. The primary objectives of the paper are to determine the prevalence of hemophilic arthropathy among individuals with hemophilia in the northeastern region of Romania, identify the most frequently affected joints, and assess whether there is a correlation between the development of hemophilic arthropathy, the type of hemophilia, and the treatment received. The secondary objectives of the work are to identify a series of particularities regarding the occurrence of the comorbidities depending on the type of hemophilia and the treatment and severity of arthropathies. Materials and Methods: We conducted a retrospective study that included 36 adults with hemophilia A and B. The status of the osteoarticular system was evaluated using the modified Hemophilia Joint Health Score (mHJHS). Twelve joints were evaluated using the following parameters: swelling, duration of swelling, muscle atrophy, joint pain, crepitus on motion, flexion loss, and extension loss. Results and Discussions: The most severe damage was found in the joints of the knees, ankles, elbows, and wrists. In the knees, severe damage was noted significantly more frequently in the right knee (50% vs. 33.3%; <i>p</i> = 0.001). In the ankles, a higher frequency of mild damage to the left ankle was noted (44.4% vs. 27.8%; <i>p</i> = 0.002). The severe form of hemophilia was correlated with severe joint damage (<i>p</i> < 0.05). Comorbidities like cardiovascular disease, obesity, viral infection (HCV infection), and gastrointestinal disease were found in the hemophilia population of our study. All patients with HCV infection had severe joint damage, while 38.5% of patients without HCV infection had mild joint damage, and 30.8% had no joint damage (<i>p</i> = 0.001). In all patients with HCV virus infection, the treatment was short-term substitution (intermittent prophylaxis), while in 53.8% of patients without HCV virus infection, the treatment consisted of continuous prophylaxis (<i>p</i> = 0.001). Conclusions: It is currently essential to determine methods for comprehensive hemophilia care that involves multidisciplinary medical services necessary for the diagnosis, treatment, and management of the condition and its complications and comorbidities. |
| format | Article |
| id | doaj-art-b1a0e8d5de3840878f27ed83020141bf |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
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| series | Life |
| spelling | doaj-art-b1a0e8d5de3840878f27ed83020141bf2025-08-20T02:18:09ZengMDPI AGLife2075-17292025-03-0115453010.3390/life15040530Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary ApproachCristina Claudia Tarniceriu0Loredana Liliana Hurjui1Daniela Maria Tanase2Anca Haisan3Razvan Tudor Tepordei4Gabriel Statescu5Simona Alice Partene Vicoleanu6Ancuta Lupu7Vasile Valeriu Lupu8Manuela Ursaru9Alin Horatiu Nedelcu10Department of Morpho-Functional Science I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Science II, Discipline of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Emergency Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Science I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Science I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Science I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgical Sciences I, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgical Sciences I, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morpho-Functional Science I, Discipline of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaBackground: Articular damage is a marker of hereditary hemophilia, especially affecting the large joints of the upper and lower limbs. This retrospective study aimed to emphasize that hereditary coagulopathies, specifically hemophilia A and B, require a multidisciplinary approach due to their complex nature. The primary objectives of the paper are to determine the prevalence of hemophilic arthropathy among individuals with hemophilia in the northeastern region of Romania, identify the most frequently affected joints, and assess whether there is a correlation between the development of hemophilic arthropathy, the type of hemophilia, and the treatment received. The secondary objectives of the work are to identify a series of particularities regarding the occurrence of the comorbidities depending on the type of hemophilia and the treatment and severity of arthropathies. Materials and Methods: We conducted a retrospective study that included 36 adults with hemophilia A and B. The status of the osteoarticular system was evaluated using the modified Hemophilia Joint Health Score (mHJHS). Twelve joints were evaluated using the following parameters: swelling, duration of swelling, muscle atrophy, joint pain, crepitus on motion, flexion loss, and extension loss. Results and Discussions: The most severe damage was found in the joints of the knees, ankles, elbows, and wrists. In the knees, severe damage was noted significantly more frequently in the right knee (50% vs. 33.3%; <i>p</i> = 0.001). In the ankles, a higher frequency of mild damage to the left ankle was noted (44.4% vs. 27.8%; <i>p</i> = 0.002). The severe form of hemophilia was correlated with severe joint damage (<i>p</i> < 0.05). Comorbidities like cardiovascular disease, obesity, viral infection (HCV infection), and gastrointestinal disease were found in the hemophilia population of our study. All patients with HCV infection had severe joint damage, while 38.5% of patients without HCV infection had mild joint damage, and 30.8% had no joint damage (<i>p</i> = 0.001). In all patients with HCV virus infection, the treatment was short-term substitution (intermittent prophylaxis), while in 53.8% of patients without HCV virus infection, the treatment consisted of continuous prophylaxis (<i>p</i> = 0.001). Conclusions: It is currently essential to determine methods for comprehensive hemophilia care that involves multidisciplinary medical services necessary for the diagnosis, treatment, and management of the condition and its complications and comorbidities.https://www.mdpi.com/2075-1729/15/4/530hemophiliaarthropathiescomorbiditiesjoint damageHCV infection |
| spellingShingle | Cristina Claudia Tarniceriu Loredana Liliana Hurjui Daniela Maria Tanase Anca Haisan Razvan Tudor Tepordei Gabriel Statescu Simona Alice Partene Vicoleanu Ancuta Lupu Vasile Valeriu Lupu Manuela Ursaru Alin Horatiu Nedelcu Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach Life hemophilia arthropathies comorbidities joint damage HCV infection |
| title | Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach |
| title_full | Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach |
| title_fullStr | Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach |
| title_full_unstemmed | Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach |
| title_short | Inherited Hemophilia—A Multidimensional Chronic Disease That Requires a Multidisciplinary Approach |
| title_sort | inherited hemophilia a multidimensional chronic disease that requires a multidisciplinary approach |
| topic | hemophilia arthropathies comorbidities joint damage HCV infection |
| url | https://www.mdpi.com/2075-1729/15/4/530 |
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