Individualized therapy guided by single-cell sequencing in anti-GABAAR encephalitis

Individualized therapy guided by single-cell sequencing in anti-GABAAR encephalitis

Abstract We presented a patient with refractory anti-GABAA-R encephalitis, and constructed libraries for single-cell sequencing from the patient’s peripheral blood mononuclear cells (PBMCs), cerebrospinal fluid cells, as well as four healthy volunteer’s PBMCs. A distinct group of monoclonal CD8+ T c...

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Main Authors: Yaqing Shu, Yu Huang, Qihui Li, Huilu Li, Zhibin Li, Jinlong Ye, Jianning Chen, Jianfang Li, Ling Fang, Jing Li, Yi Lu, Libao Liu, Yongjian Luo, Zhanhang Wang, Zhengqi Lu, Zhongxi Huang, Fuhua Peng, Wei Qiu
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03300-y
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Summary:Abstract We presented a patient with refractory anti-GABAA-R encephalitis, and constructed libraries for single-cell sequencing from the patient’s peripheral blood mononuclear cells (PBMCs), cerebrospinal fluid cells, as well as four healthy volunteer’s PBMCs. A distinct group of monoclonal CD8+ T cells and an abnormal JAK-STAT signaling pathway was implicated in the disease. The cross-reactive protein LIM-domain-only protein 5 (LMO5) identified in the patient’s thymoma, prompted the activation of the specific CD8+ T cells. Furthermore, in vitro analysis revealed the involvement of the JAK-STAT pathway in LMO5-induced CD8+T cell activation, a process effectively suppressed by tofacitinib, which improved the patient’s clinical outcome.
ISSN:2158-3188

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