Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing
Abstract Diabetes mellitus (DM) poses a significant global health challenge, with diabetic foot ulcers (DFUs) standing as a serious consequence of this metabolic disorder. The intricate interplay of peripheral neuropathy, compromised blood supply, susceptibility to infections, and delayed healing pr...
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| Format: | Article |
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Springer
2025-03-01
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| Series: | Discover Materials |
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| Online Access: | https://doi.org/10.1007/s43939-025-00227-5 |
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| author | Soo Ghee Yeoh Yun Khoon Liew May Lee Low Wei Meng Lim Norizah Abdul Rahman Lai Chun Wong Yoon Yee Then |
| author_facet | Soo Ghee Yeoh Yun Khoon Liew May Lee Low Wei Meng Lim Norizah Abdul Rahman Lai Chun Wong Yoon Yee Then |
| author_sort | Soo Ghee Yeoh |
| collection | DOAJ |
| description | Abstract Diabetes mellitus (DM) poses a significant global health challenge, with diabetic foot ulcers (DFUs) standing as a serious consequence of this metabolic disorder. The intricate interplay of peripheral neuropathy, compromised blood supply, susceptibility to infections, and delayed healing processes in diabetic patients underscores the urgency for innovative wound management strategies. This review delves into the promising realm of electrospun metal–organic framework (MOF)-based nanofibers loaded with natural therapeutic agents, offering a multifaceted approach to accelerate diabetic wound healing by offering synergistic anti-inflammatory, anti-oxidant, and anti-bacterial properties. The incorporation of MOFs, characterized by their inorganic porous structures, alongside polymeric nanofibers, has the potential to enhance drug loading capacity and prevent burst release effect of nanofibers. This paper aims to provide a comprehensive understanding of the diabetic wound healing process, elucidate the properties of MOFs with exceptional porosity and high surface-to-volume ratios for extended and controlled drug release, and highlight the unique attributes of electrospun nanofibers in creating a conducive wound environment for tissue repair, re-epithelialization and vascularization. Additionally, this review explores seven natural therapeutic agents—borneol, clove essential oil, curcumin, chrysin, honey, aloe vera, quercetin, and rutin, showcasing their potential in diabetic wound care by enhancing the granulation tissue formation, collagen deposition, tissue remodeling and wound contraction. This comprehensive examination serves as a valuable resource for researchers and practitioners seeking advanced solutions for the management of diabetic foot ulcers. Graphical Abstract |
| format | Article |
| id | doaj-art-b190bb8f813e40a6889bf57c695f1176 |
| institution | DOAJ |
| issn | 2730-7727 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Materials |
| spelling | doaj-art-b190bb8f813e40a6889bf57c695f11762025-08-20T02:49:12ZengSpringerDiscover Materials2730-77272025-03-015113310.1007/s43939-025-00227-5Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healingSoo Ghee Yeoh0Yun Khoon Liew1May Lee Low2Wei Meng Lim3Norizah Abdul Rahman4Lai Chun Wong5Yoon Yee Then6School of Postgraduate Studies, IMU UniversityDepartment of Life Sciences, School of Pharmacy, IMU UniversityFaculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur CampusSchool of Pharmacy, Monash University MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmacy, IMU UniversityDepartment of Pharmaceutical Chemistry, School of Pharmacy, IMU UniversityAbstract Diabetes mellitus (DM) poses a significant global health challenge, with diabetic foot ulcers (DFUs) standing as a serious consequence of this metabolic disorder. The intricate interplay of peripheral neuropathy, compromised blood supply, susceptibility to infections, and delayed healing processes in diabetic patients underscores the urgency for innovative wound management strategies. This review delves into the promising realm of electrospun metal–organic framework (MOF)-based nanofibers loaded with natural therapeutic agents, offering a multifaceted approach to accelerate diabetic wound healing by offering synergistic anti-inflammatory, anti-oxidant, and anti-bacterial properties. The incorporation of MOFs, characterized by their inorganic porous structures, alongside polymeric nanofibers, has the potential to enhance drug loading capacity and prevent burst release effect of nanofibers. This paper aims to provide a comprehensive understanding of the diabetic wound healing process, elucidate the properties of MOFs with exceptional porosity and high surface-to-volume ratios for extended and controlled drug release, and highlight the unique attributes of electrospun nanofibers in creating a conducive wound environment for tissue repair, re-epithelialization and vascularization. Additionally, this review explores seven natural therapeutic agents—borneol, clove essential oil, curcumin, chrysin, honey, aloe vera, quercetin, and rutin, showcasing their potential in diabetic wound care by enhancing the granulation tissue formation, collagen deposition, tissue remodeling and wound contraction. This comprehensive examination serves as a valuable resource for researchers and practitioners seeking advanced solutions for the management of diabetic foot ulcers. Graphical Abstracthttps://doi.org/10.1007/s43939-025-00227-5Metal–organic frameworkDiabetic wound healingNanofiberNatural therapeutic agents |
| spellingShingle | Soo Ghee Yeoh Yun Khoon Liew May Lee Low Wei Meng Lim Norizah Abdul Rahman Lai Chun Wong Yoon Yee Then Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing Discover Materials Metal–organic framework Diabetic wound healing Nanofiber Natural therapeutic agents |
| title | Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| title_full | Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| title_fullStr | Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| title_full_unstemmed | Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| title_short | Electrospun metal–organic framework-based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| title_sort | electrospun metal organic framework based nanofibers with natural therapeutic agents for enhanced diabetic wound healing |
| topic | Metal–organic framework Diabetic wound healing Nanofiber Natural therapeutic agents |
| url | https://doi.org/10.1007/s43939-025-00227-5 |
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