Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency

Climate change and the energy crisis, driven by excessive CO<sub>2</sub> emissions, have emerged as pressing global challenges. The conversion of CO<sub>2</sub> into high-value chemicals not only mitigates atmospheric CO<sub>2</sub> levels but also optimizes carbo...

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Main Authors: Yunhan Cao, Pengyan Yang, Rui Zhao, Fenghuan Wang
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/30/2/251
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author Yunhan Cao
Pengyan Yang
Rui Zhao
Fenghuan Wang
author_facet Yunhan Cao
Pengyan Yang
Rui Zhao
Fenghuan Wang
author_sort Yunhan Cao
collection DOAJ
description Climate change and the energy crisis, driven by excessive CO<sub>2</sub> emissions, have emerged as pressing global challenges. The conversion of CO<sub>2</sub> into high-value chemicals not only mitigates atmospheric CO<sub>2</sub> levels but also optimizes carbon resource utilization. Enzyme-catalyzed carbon technology offers a green and efficient approach to CO<sub>2</sub> conversion. However, free enzymes are prone to inactivation and denaturation under reaction conditions, which limit their practical applications. Metal–organic frameworks (MOFs) serve as effective carriers for enzyme immobilization, offering porous crystalline structures that enhance enzyme stability. Moreover, their high specific surface area facilitates strong gas adsorption, making enzyme@MOF composites particularly advantageous for CO<sub>2</sub> catalytic conversion. In this paper, we review the synthesis technologies and the application of enzyme@MOFs in CO<sub>2</sub> catalytic conversion. Furthermore, the strategies, including the enhancement of CO<sub>2</sub> utilization, coenzyme regeneration efficiency, and substrate mass transfer efficiency, are also discussed to further improve the efficiency of enzyme@MOFs in CO<sub>2</sub> conversion. The aim of this review is to present innovative ideas for future research and to highlight the potential applications of enzyme@MOFs in achieving efficient CO<sub>2</sub> conversion.
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spelling doaj-art-b18bb0661f8b45f48f7096ef080f85482025-01-24T13:43:15ZengMDPI AGMolecules1420-30492025-01-0130225110.3390/molecules30020251Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion EfficiencyYunhan Cao0Pengyan Yang1Rui Zhao2Fenghuan Wang3School of Light Industry, Beijing Technology and Business University (BTBU), Beijing 100048, ChinaSchool of Light Industry, Beijing Technology and Business University (BTBU), Beijing 100048, ChinaSchool of Light Industry, Beijing Technology and Business University (BTBU), Beijing 100048, ChinaSchool of Light Industry, Beijing Technology and Business University (BTBU), Beijing 100048, ChinaClimate change and the energy crisis, driven by excessive CO<sub>2</sub> emissions, have emerged as pressing global challenges. The conversion of CO<sub>2</sub> into high-value chemicals not only mitigates atmospheric CO<sub>2</sub> levels but also optimizes carbon resource utilization. Enzyme-catalyzed carbon technology offers a green and efficient approach to CO<sub>2</sub> conversion. However, free enzymes are prone to inactivation and denaturation under reaction conditions, which limit their practical applications. Metal–organic frameworks (MOFs) serve as effective carriers for enzyme immobilization, offering porous crystalline structures that enhance enzyme stability. Moreover, their high specific surface area facilitates strong gas adsorption, making enzyme@MOF composites particularly advantageous for CO<sub>2</sub> catalytic conversion. In this paper, we review the synthesis technologies and the application of enzyme@MOFs in CO<sub>2</sub> catalytic conversion. Furthermore, the strategies, including the enhancement of CO<sub>2</sub> utilization, coenzyme regeneration efficiency, and substrate mass transfer efficiency, are also discussed to further improve the efficiency of enzyme@MOFs in CO<sub>2</sub> conversion. The aim of this review is to present innovative ideas for future research and to highlight the potential applications of enzyme@MOFs in achieving efficient CO<sub>2</sub> conversion.https://www.mdpi.com/1420-3049/30/2/251CO<sub>2</sub> conversionenzyme@MOFcoenzyme regenerationmulti-enzyme co-immobilization
spellingShingle Yunhan Cao
Pengyan Yang
Rui Zhao
Fenghuan Wang
Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
Molecules
CO<sub>2</sub> conversion
enzyme@MOF
coenzyme regeneration
multi-enzyme co-immobilization
title Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
title_full Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
title_fullStr Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
title_full_unstemmed Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
title_short Recent Progress in Enzyme Immobilization to Metal–Organic Frameworks to Enhance the CO<sub>2</sub> Conversion Efficiency
title_sort recent progress in enzyme immobilization to metal organic frameworks to enhance the co sub 2 sub conversion efficiency
topic CO<sub>2</sub> conversion
enzyme@MOF
coenzyme regeneration
multi-enzyme co-immobilization
url https://www.mdpi.com/1420-3049/30/2/251
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AT pengyanyang recentprogressinenzymeimmobilizationtometalorganicframeworkstoenhancethecosub2subconversionefficiency
AT ruizhao recentprogressinenzymeimmobilizationtometalorganicframeworkstoenhancethecosub2subconversionefficiency
AT fenghuanwang recentprogressinenzymeimmobilizationtometalorganicframeworkstoenhancethecosub2subconversionefficiency