Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species
The present study aims at evaluating the correlation between the free radical formation and the healing action of lower limbs’ ulcers in a randomized controlled trial with the use of an adhesive derived from natural latex associated with a light-emitting diode (LED) circuit. The sample consists of 1...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4641364 |
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| author | Alberto López-Delis Suélia de S. Rodrigues Fleury Rosa Paulo Eduardo Narcizo de Souza Marcella Lemos Brettas Carneiro Mário Fabrício Fleury Rosa Yasmin Carneiro Lobo Macedo Fabiane Hiratsuka Veiga-Souza Adson Ferreira da Rocha |
| author_facet | Alberto López-Delis Suélia de S. Rodrigues Fleury Rosa Paulo Eduardo Narcizo de Souza Marcella Lemos Brettas Carneiro Mário Fabrício Fleury Rosa Yasmin Carneiro Lobo Macedo Fabiane Hiratsuka Veiga-Souza Adson Ferreira da Rocha |
| author_sort | Alberto López-Delis |
| collection | DOAJ |
| description | The present study aims at evaluating the correlation between the free radical formation and the healing action of lower limbs’ ulcers in a randomized controlled trial with the use of an adhesive derived from natural latex associated with a light-emitting diode (LED) circuit. The sample consists of 15 participants with lower limb lesions divided into three groups: group 1 case (5 participants) received the proposed dressing system adhesive of the natural latex associated with the LED circuit; group 2 control (5 participants) received the dressings at home performed by nurses according to and established by the clinic of wounds (treated with calcium alginate or silver foam); and group 3 (5 participants) also received the dressing in their homes with the use of the dressing adhesive derived from the natural latex associated with the LED circuit. The collected data were analyzed qualitatively and quantitatively by electron paramagnetic resonance for determination of free radical formation. Kruskal-Wallis statistical test was used to evaluate the effect of treatment on the lower limb’s ulcer cicatrization process and its correlation with free radical. The results obtained corroborated the hypothesis about the reduction of the quantity of these molecules in the end of treatment related to the healing wound. |
| format | Article |
| id | doaj-art-b186f286ea364ee0a129b03b00366e19 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b186f286ea364ee0a129b03b00366e192025-08-20T02:23:35ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/46413644641364Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen SpeciesAlberto López-Delis0Suélia de S. Rodrigues Fleury Rosa1Paulo Eduardo Narcizo de Souza2Marcella Lemos Brettas Carneiro3Mário Fabrício Fleury Rosa4Yasmin Carneiro Lobo Macedo5Fabiane Hiratsuka Veiga-Souza6Adson Ferreira da Rocha7Medical Biophysics Center, University of Oriente, Santiago de Cuba, CubaBiomedical Engineering Program, University of Brasilia, Brasilia, DF, BrazilLaboratory of Electron Paramagnetic Resonance, Institute of Physics, University of Brasilia, Brasilia, DF, BrazilFaculty of Planaltina, University of Brasilia, Planaltina, GO, BrazilBiomedical Engineering Program, University of Brasilia, Brasilia, DF, BrazilBiomedical Engineering Program, University of Brasilia, Brasilia, DF, BrazilLaboratory of Biochemistry and Protein Chemistry, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, BrazilBiomedical Engineering Program, University of Brasilia, Brasilia, DF, BrazilThe present study aims at evaluating the correlation between the free radical formation and the healing action of lower limbs’ ulcers in a randomized controlled trial with the use of an adhesive derived from natural latex associated with a light-emitting diode (LED) circuit. The sample consists of 15 participants with lower limb lesions divided into three groups: group 1 case (5 participants) received the proposed dressing system adhesive of the natural latex associated with the LED circuit; group 2 control (5 participants) received the dressings at home performed by nurses according to and established by the clinic of wounds (treated with calcium alginate or silver foam); and group 3 (5 participants) also received the dressing in their homes with the use of the dressing adhesive derived from the natural latex associated with the LED circuit. The collected data were analyzed qualitatively and quantitatively by electron paramagnetic resonance for determination of free radical formation. Kruskal-Wallis statistical test was used to evaluate the effect of treatment on the lower limb’s ulcer cicatrization process and its correlation with free radical. The results obtained corroborated the hypothesis about the reduction of the quantity of these molecules in the end of treatment related to the healing wound.http://dx.doi.org/10.1155/2018/4641364 |
| spellingShingle | Alberto López-Delis Suélia de S. Rodrigues Fleury Rosa Paulo Eduardo Narcizo de Souza Marcella Lemos Brettas Carneiro Mário Fabrício Fleury Rosa Yasmin Carneiro Lobo Macedo Fabiane Hiratsuka Veiga-Souza Adson Ferreira da Rocha Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species Journal of Diabetes Research |
| title | Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species |
| title_full | Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species |
| title_fullStr | Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species |
| title_full_unstemmed | Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species |
| title_short | Characterization of the Cicatrization Process in Diabetic Foot Ulcers Based on the Production of Reactive Oxygen Species |
| title_sort | characterization of the cicatrization process in diabetic foot ulcers based on the production of reactive oxygen species |
| url | http://dx.doi.org/10.1155/2018/4641364 |
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